Spatial memory deficits in segmental trisomic Ts65Dn mice
Spatial memory deficits in segmental trisomic Ts65Dn mice
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DOI：
10.1016/s0166-4328(97)81111-4
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发表时间：
1996-12-01
影响因子：
2.7
通讯作者：
Yarowsky, OJ
中科院分区：
文献类型：
--
作者：
Demas, GE;Nelson, RJ;Yarowsky, OJ
在节段性三体16小鼠（Ts 65 Dn）中，使用12臂径向迷宫（RAM）评估空间记忆，Ts 65 Dn是唐氏综合征（DS）的潜在模型。Ts 65 Dn小鼠具有与人染色体21的远端同线的小鼠染色体16的一部分三重化。在每天8次的RAM试验中，Ts 65 Dn小鼠比对照小鼠做出更少的正确选择，并且表现在或接近偶然水平，这表明空间工作记忆的缺陷。在试验9和10中，Ts 65 Dn小鼠在最初的12个选择上表现得与对照小鼠一样好，但需要更多的选择来完成RAM。Ts 65 Dn小鼠在试验9和10中的改善表现在50天保留期后重新测试时丧失，这表明长期记忆也有缺陷。这些结果不太可能用反应偏差或感知歧视的差异来解释。Ts 65 Dn和对照小鼠在T-迷宫中的自发交替中表现出相当的性能水平，表明简单的空间记忆没有受损。在高架十字迷宫中，Ts 65 Dn小鼠没有表现出可能影响其在RAM中表现的较高焦虑水平。事实上，Ts 65 Dn小鼠在高架十字迷宫上更频繁地访问开放臂，并且比对照小鼠在开放臂上花费更多时间。总之，这些结果为Ts 65 Dn小鼠的短期和长期空间记忆缺陷提供了证据。
Spatial memory was assessed in the segmental trisomic 16 mouse (Ts65Dn), a potential model for Down syndrome (DS), using the 12-arm radial maze (RAM). Ts65Dn mice have a portion of mouse chromosome 16 syntenic to the distal end of human chromosome 21 triplicated. On each of 8 daily trials of the RAM, Ts65Dn mice made fewer correct choices than control mice and performed at or near chance levels, indicating a deficit in spatial working memory. On trials 9 and 10, Ts65Dn mice performed as well as control mice on the initial 12 choices, but required a greater number of choices to complete the RAM. The improved performance of Ts65Dn mice on trials 9 and 10 was lost when the animals were retested after a 50-day retention period, suggesting that long-term memory is also defective. These results are not likely explained by differences in either response bias or perceptual discrimination. Ts65Dn and control mice displayed comparable levels of performance in spontaneous alternation in a T-maze, demonstrating that simple spatial memory was not impaired. In the elevated plus maze, Ts65Dn mice did not display higher anxiety levels which could affect their performance in the RAM. In fact, Ts65Dn mice visited open arms on the elevated plus maze more frequently and spent more time on open arms than did control mice. Taken together, these results provide evidence for short- and long-term spatial memory deficits in Ts65Dn mice.