Efficient synthesis of Idraparinux, the anticoagulant pentasaccharide

Efficient synthesis of Idraparinux, the anticoagulant pentasaccharide
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DOI:
10.1016/j.bmcl.2009.03.155
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发表时间:
2009-07-15
影响因子:
2.7
通讯作者:
Yu, Biao
Yu, Biao
中科院分区:
医学4区
文献类型:
--
作者:
Chen, Chen;Yu, Biao

文献摘要

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开发了一种有效的[DEF+GH]路线来合成Idraparinux,Idraparinux是肝素独特的抗凝血酶III结合结构域的完全O-硫酸、O-甲基化的模拟物。(C)2009爱思唯尔有限公司。保留所有权利。
An efficient [DEF+GH] route was developed to the synthesis of Idraparinux, which is a fully O-sulfated, O-methylated mimic of the unique Antithrombin III binding domain of heparin. (C) 2009 Elsevier Ltd. All rights reserved.