Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma
Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma
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DOI：
10.1016/s0161-6420(03)00833-9
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发表时间：
2004-02-01
期刊：
影响因子：
13.7
通讯作者：
Gregory, JW
中科院分区：
文献类型：
--
作者：
Goyal, R;Watts, P;Gregory, JW
目的：评价激素注射治疗眼周毛细血管瘤对肾上腺功能和身体成分的影响。设计：非对照、干预性病例系列。参与者：4例眼周血管瘤患者。方法：4例患有眼周血管瘤的白人女性婴儿接受激素注射曲安奈德和倍他米松的联合治疗。主要观察指标：通过连续测量基础血清皮质醇浓度、对Synacten刺激试验的反应、生长和体重增加，以及1例更详细的身体成分测量，对婴儿进行监测。结果：3例患者的循环血清皮质醇浓度和对Synacten刺激试验的皮质醇反应被长期抑制，所有4例均明显无法生长。结论：激素注射治疗眼周毛细血管瘤后肾上腺抑制是一个潜在的威胁生命的并发症。不能茁壮成长也是治疗的一个常见副作用。眼科医生应在咨询儿科内分泌科医生的情况下进行上述治疗。(C)2004年，由美国眼科学会提供。
Purpose: To evaluate the effects of steroid injections for periocular capillary hemangioma on adrenal function and body composition.Design: Noncomparative, interventional case series.Participants: Four patients with periocular hemangioma.Methods: Four white female infants with sight-threatening periocular hemangiomata received a combination of steroid injections of triamcinolone and betamethasone. In the first 2 cases, injections were perilesional and in the other 2, intralesional.Main Outcome Measures: The infants were monitored by serial measurements of basal serum cortisol concentrations, responses to the Synacthen stimulation test, measurement of growth and of weight gain, and, in one case, more detailed anthropometric measures of body composition.Results: Prolonged suppression of circulating serum cortisol concentrations and cortisol responses to the Synacthen stimulation test were noted in 3 cases, and marked failure to thrive was noted in all 4 cases.Conclusions: Adrenal suppression after steroid injection for periocular capillary hemangioma is a potentially life-threatening complication. Failure to thrive is also a frequent side effect of treatment. Ophthalmologists should undertake the above treatment in consultation with a pediatric endocrinologist. (C) 2004 by the American Academy of Ophthalmology.