COLCHICINE INTOXICATION - CLINICAL-PHARMACOLOGY, RISK-FACTORS, FEATURES, AND MANAGEMENT
COLCHICINE INTOXICATION - CLINICAL-PHARMACOLOGY, RISK-FACTORS, FEATURES, AND MANAGEMENT
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DOI：
10.1016/0049-0172(91)90003-i
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发表时间：
1991-12-01
影响因子：
5
通讯作者：
LEVY, M
中科院分区：
文献类型：
--
作者：
PUTTERMAN, C;BENCHETRIT, E;LEVY, M
使用秋水仙碱治疗急性痛风性关节炎可以追溯到古代。近年来，秋水仙碱也已成功地用于其他各种风湿性和非风湿性疾病。根据既定的治疗指南使用秋水仙碱是一种安全的药物。然而，如果有意摄入或超过推荐剂量，毒性可能相当大。秋水仙碱中毒的特点是多器官受累，并且与大量使用该药物有关的预后不良。治疗基本上是支持性和对症的，因为秋水仙碱迅速分布和结合到受影响的组织。使用抗秋水仙碱抗体是一种新的方法，在实验模型中显示出希望。重要的研究问题涉及肝脏和肾脏疾病对秋水仙碱代谢的影响，秋水仙碱水平在中毒诊断和预测中的应用，以及对人类秋水仙碱中毒的免疫毒性治疗的应用。
The use of colchicine for acute gouty arthritis dates to ancient times. In recent years, colchicine also has been used successfully for various other rheumatic and nonrheumatic conditions. Colchicine is a safe drug when used according to established therapeutic guidelines. However, toxicity can be considerable if ingested intentionally or if the recommended doses are exceeded. Colchicine intoxication is characterized by multiorgan involvement and by the poor prognosis associated with administration of large amounts of the drug. Therapy is basically supportive and symptomatic because of the rapid distribution and binding of colchicine to the affected tissues. Use of anticolchicine antibodies is a novel approach that has shown promise in experimental models. Important research questions pertain to the effect of liver and kidney disease on colchicine metabolism, use of colchicine levels in the diagnosis of intoxication and for prognostication, and application of immunotoxicotherapy for colchicine poisoning in humans.