Nucleus accumbens mediates relative motivation for rewards in the absence of choice.
Nucleus accumbens mediates relative motivation for rewards in the absence of choice.
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DOI：
10.3389/fnhum.2011.00087
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发表时间：
2011
影响因子：
2.9
通讯作者：
Huettel SA
中科院分区：
文献类型：
--
作者：
Clithero JA;Reeck C;Carter RM;Smith DV;Huettel SA
为了将选择与其之前的神经状态分离开来，必须在没有选择的情况下捕获与预期结果相关的动机。然而，介导动机行为特质的神经机制，特别是涉及复杂经济偏好的神经机制，很少在没有公开决策的情况下进行研究。当参与者期望从两种不同的方式获得奖励：金钱奖励和糖果奖励时，我们对大量参与者进行了功能性磁共振成像。利用获得奖励目标的反应时间，构建了不同奖励类型的相对动机指数。伏隔核（NAcc）和前脑岛（aINS）的激活预测了我们的奖励模式之间相对动机的个体差异。然而，NAcc激活介导了aINS的作用，表明NAcc可能是这种相对权重的来源。这些结果表明，即使在没有明确选择的情况下，奖励效能的神经特质也存在，并扩展了NAcc作为这种无选择动机的关键脑区的作用。
To dissociate a choice from its antecedent neural states, motivation associated with the expected outcome must be captured in the absence of choice. Yet, the neural mechanisms that mediate behavioral idiosyncrasies in motivation, particularly with regard to complex economic preferences, are rarely examined in situations without overt decisions. We employed functional magnetic resonance imaging in a large sample of participants while they anticipated earning rewards from two different modalities: monetary and candy rewards. An index for relative motivation toward different reward types was constructed using reaction times to the target for earning rewards. Activation in the nucleus accumbens (NAcc) and anterior insula (aINS) predicted individual variation in relative motivation between our reward modalities. NAcc activation, however, mediated the effects of aINS, indicating the NAcc is the likely source of this relative weighting. These results demonstrate that neural idiosyncrasies in reward efficacy exist even in the absence of explicit choices, and extend the role of NAcc as a critical brain region for such choice-free motivation.
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