Amphiphile regulated ionic-liquid-based aqueous biphasic systems with tunable LCST and extraction behavior
Amphiphile regulated ionic-liquid-based aqueous biphasic systems with tunable LCST and extraction behavior
复制标题
具有可调 LCST 和萃取行为的两亲物调节的基于离子液体的水性双相系统
DOI：
10.1016/j.colsurfa.2022.130172
复制
发表时间：
2022-09-19
影响因子：
5.2
通讯作者：
Gao，Xinpei
中科院分区：
文献类型：
--
作者：
Zhang，Yanan;Lu，Fei;Gao，Xinpei
具有可调低临界溶解温度（LCST）特性的离子液体（IL）/H2O混合物在液-液相分离与纯化领域具有诱人的前景。本文中，评价了不同类型的两亲物对基于IL（[P4444][DMBS]）的水性双相系统（ABS）的简易调节。有趣的是，两性离子3-（1-十二烷基-3-咪唑基）丙磺酸盐（DIPS）的加入显著提高了IL水溶液的相分离温度，而阴离子十二烷基苯磺酸钠（SDBS）和十二烷基苯磺酸（DBSA）的加入则降低了IL水溶液的相分离温度。可调相分离温度范围为10至90 °C，几乎覆盖ABS的全部可用温度范围。通过等温滴定量热法、核磁共振氢谱和分子动力学模拟研究了两亲物添加剂对IL/H2O混合物LCST行为的调节机制。两性离子型DIPS通过静电屏蔽作用提高了LCST，而阴离子型SDBS和DBSA通过离子交换作用降低了LCST。作为概念的证明，两亲物调节的ABS被证明选择性地分离脂肪族和芳香族氨基酸。
Ionic liquid (IL)/H2O mixtures with tunable lower critical solution temperature (LCST) behavior exhibit tantalizing prospect in the field of liquid-liquid phase separation and purification. Herein, different types of amphiphiles were evaluated for the facile regulation of IL ([P4444][DMBS]) based aqueous biphasic systems (ABSs). Interestingly, the addition of zwitterionic 3-(1-dodecyl-3-imidazolio) propanesulfonate (DIPS) remarkably increases the phase separation temperature of IL aqueous solution, while the addition of anionic sodium dodecyl benzene sulfonate (SDBS) and dodecyl-benzenesulphonic acid (DBSA) results in decreasing of the phase separation temperature. The tunable phase separation temperature ranges from 10 to 90 °C, which almost cover the full usable temperature range of ABSs. The regulation mechanism of amphiphile additives on the LCST behavior of IL/H2O mixtures was investigated through isothermal titration calorimetry,1H NMR spectroscopy and molecular dynamics simulations. Briefly, the addition of zwitterionic DIPS increased LCST through electrostatic shielding effect, while the addition of anionic SDBS and DBSA decreased LCST through ion exchange effect. As a proof of concept, the amphiphile regulated ABSs were demonstrated to selectively separate aliphatic and aromatic amino acids.