Functional status after primary surgical therapy for squamous cell carcinoma of the base of the tongue
Functional status after primary surgical therapy for squamous cell carcinoma of the base of the tongue
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DOI：
10.1002/hed.10015
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发表时间：
2002-02-01
影响因子：
2.9
通讯作者：
Shah, JP
中科院分区：
文献类型：
--
作者：
Friedlander, P;Caruana, S;Shah, JP
介绍。生活质量分析对于确定头颈癌治疗后的最终结果至关重要。当治疗的功能性后遗症引起显著的发病率时，这一点尤为重要。本研究的目的是评估一组接受初级手术治疗的舌底鳞状细胞癌患者的功能状况。从1979年到1993年，在我们的机构，我们确定了93例接受舌底切除术作为鳞状细胞癌的主要治疗方法的患者。需要喉切除术的患者被排除在本组之外。选取48名幸存者，采用头颈癌患者工作状态量表（PSS）和Karnofsky工作状态量表（KPS）进行问卷调查。数据以数字形式报告，0代表最差分数，100代表最好分数。26名患者完成了问卷调查。有19名男性和7名女性。他们的平均生存时间为8.6年。2例原发肿瘤分期为T1, 17例为T2, 7例为T3。在饮食正常性评价方面，全组平均得分为73.1分（范围20-100），言语可理解性平均得分为80.8分（范围50-100），公共场合进食平均得分为79.8分（范围0-00）。平均KPS为90（范围60-100）。当比较早期（T1和T2）和晚期（T3）疾病时，PSS和KPS无显著差异。当比较年轻（50岁）患者时，PSS评分无显著差异。年轻患者的KPS明显高于老年患者：平均97.5 vs 86.4 (p
Introduction. Quality-of-life analysis is essential in determining the eventual outcome after treatment for head and neck cancer. This is particularly important when functional sequelae of treatment cause significant morbidity. The purpose of this study is to evaluate the functional status of a group of patients who had undergone primary surgical therapy for squamous cell carcinoma of the base of the tongue.Methods. At our institution from 1979 to 1993, we identified 93 patients who had undergone resection of the base of the tongue as primary treatment for squamous cell carcinoma. Patients who required laryngectomy were excluded from this group. Forty-eight survivors were identified, and the questionnaires included the Performance Status Scale for Head and Neck Cancer Patients (PSS) and the Karnofsky Performance Status Scale (KPS). The data were reported numerically, with 0 representing the worst score and 100 representing the best score.Results. Twenty-six patients completed the questionnaires. There were 19 men and 7 women. Their mean survival time was 8.6 years. Two patients had their primary tumors staged as T1, 17 patients had T2, and 7 patients had T3 disease. When evaluating the normalcy of diet, the mean score for the whole group was 73.1 (range, 20-100), the mean score for understandability of speech was 80.8 (range, 50-100), and the mean score for eating in public was 79.8 (range, 0-00). The mean KPS was 90 (range, 60-100). When comparing early (T1 and T2) with advanced (T3) disease, there were no significant differences in PSS and KPS. When comparing younger (50 years) patients, there were no significant differences in PSS scores. Younger patients had a significantly higher KPS than older patients: mean, 97.5 vs 86.4 (p