Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer.

Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer.
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具有优化核心尺寸的磁性聚合物纳米气泡,用于前列腺癌的 MRI/超声双峰分子成像。

DOI:
10.2217/nnm-2020-0188
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发表时间:
2020-12
期刊:
Nanomedicine (Lond)
影响因子:
--
通讯作者:
Chen Yaqing
Chen Yaqing
中科院分区:
其他
文献类型:
--
作者:
Zhu Yunkai;Sun Ying;Liu Weiyong;Guan Wenbin;Liu Huanhuan;Duan Yourong;Chen Yaqing

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Aim: To design MRI/ultrasound (US) dual modality imaging probes with optimized size for prostate cancer imaging by targeting prostate-specific membrane antigen (PSMA). Materials & methods: The PSMA-targeting polypeptide-nanobubbles (PP-NBs) with core size of 400 and 700 nm were fabricated and evaluated. Results: With excellent physical property and specificity, PP-NBs of both core size could image PSMA expression in prostate cancer xenografts. Particularly, 400 nm PP-NBs generated higher PSMA-specific MRI/US dual modality contrast enhancement than 700 nm PP-NBs in correlation with histopathologic findings. Conclusion: Benefit from the smaller core size, 400 nm PP-NBs had higher permeability and specificity than 700 nm PP-NBs, hence producing better PSMA-specific MRI/US dual modality imaging.
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