Intensity and amount of physical activity in relation to insulin sensitivity - The Insulin Resistance Atherosclerosis Study
Intensity and amount of physical activity in relation to insulin sensitivity - The Insulin Resistance Atherosclerosis Study
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DOI：
10.1001/jama.279.9.669
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发表时间：
1998-03-04
影响因子：
120.7
通讯作者：
Bergman, RN
中科院分区：
文献类型：
--
作者：
Mayer-Davis, EJ;D'Agostino, R;Bergman, RN
背景。-运动训练与改善胰岛素敏感性（S-I）有关，但习惯性非剧烈活动的潜在影响尚不确定。确定习惯性的非剧烈体力活动以及剧烈的整体活动是否与更好的S-I设计相关。多文化流行病学研究。设置。-在加利福尼亚州奥克兰、加利福尼亚州洛杉矶、圣路易斯谷、科尔和德克萨斯州圣安东尼奥进行的胰岛素抵抗动脉粥样硬化研究。共有1467名男性和女性的非裔美国人，西班牙裔，和非西班牙裔白色种族，年龄40至69岁，葡萄糖耐量范围从正常到轻度非胰岛素依赖型糖尿病。通过静脉葡萄糖耐量试验测量的胰岛素敏感性。结果。-每周参加5次或更多次剧烈活动的个体的平均S-I为1.59 min（-1）μ U-1.mL（-1 10（-4）μ U-1.mL）。（95%可信区间[CI]，1.39-1.79），而很少或从不参加剧烈活动的受试者为0.90（95% CI，0.83-0.97），调整潜在混杂因素后（P
Context.-Exercise training is associated with improved insulin sensitivity (S-I), but the potential impact of habitual, nonvigorous activity is uncertain.Objective.-To determine whether habitual, nonvigorous physical activity, as well as vigorous and overall activity, is associated with better S-I.Design.-A multicultural epidemiologic study.Setting.-The Insulin Resistance Atherosclerosis Study, conducted in Oakland, Calif; Los Angeles, Calif; the San Luis Valley, Cole; and San Antonio, Tex.Participants.-A total of 1467 men and women of African American, Hispanic, and non-Hispanic white ethnicity, aged 40 to 69 years, with glucose tolerance ranging from normal to mild non-insulin-dependent diabetes mellitus.Main Outcome Measure.-Insulin sensitivity as measured by an intravenous glucose tolerance test.Results.-The mean S-I for individuals who participated in vigorous activity 5 or more times per week was 1.59 min(-1).mu U-1.mL(-1).10(-4) (95% confidence interval [CI], 1.39-1.79) compared with 0.90 (95% CI, 0.83-0.97) for those who rarely or never participated in vigorous activity, after adjusting for potential confounders (P