β-cell dedifferentiation in diabetes is important, but what is it?
β-cell dedifferentiation in diabetes is important, but what is it?
复制标题
DOI：
10.4161/isl.27494
复制
发表时间：
2013-09
期刊：
影响因子：
2.2
通讯作者：
Bonner-Weir S
中科院分区：
文献类型：
--
作者：
Weir GC;Aguayo-Mazzucato C;Bonner-Weir S
这篇评论讨论了糖尿病中β细胞去分化的概念，这是重要的，但没有很好地定义。广义的解释是，分化状态已经丧失，这意味着基因表达以及结构和功能元件的变化。因此，完全成熟的健康辟田胞将具有其独特的分化特征，但成熟细胞和老辟田胞将具有不同的基因表达模式，因此可能被认为是去分化的。去分化的意义现在正在争论，因为糖尿病状态下的β细胞失去其分化状态的组分，这导致胰岛素分泌严重功能障碍。这种变化的主要原因被认为是葡萄糖毒性（葡萄糖毒性），治疗降低葡萄糖水平导致功能恢复。要讨论的一个问题是去分化的β细胞是否返回到多能前体细胞表型，或者它们是否遵循不同的去分化途径。
This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully mature healthy β cell will have its unique differentiation characteristics, but maturing cells and old β cells will have different patterns of gene expression and might therefore be considered as dedifferentiated. The meaning of dedifferentiation is now being debated because β cells in the diabetic state lose components of their differentiated state, which results in severe dysfunction of insulin secretion. The major cause of this change is thought to be glucose toxicity (glucotoxicity) and that lowering glucose levels with treatment results in some restoration of function. An issue to be discussed is whether dedifferentiated β cells return to a multipotent precursor cell phenotype or whether they follow a different pathway of dedifferentiation.
登录
查看更多内容
影响因子：
64.5
作者：
Talchai C;Xuan S;Lin HV;Sussel L;Accili D
通讯作者：
Accili D
影响因子：
7.7
作者：
Olsson R;Carlsson PO
通讯作者：
Carlsson PO
影响因子：
--
作者：
Kondo, Takuma;El Khattabi, Ilham;Sharma, Arun
通讯作者：
Sharma, Arun
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
慢性高血糖引发糖尿病动物模型胰腺β细胞分化丧失
影响因子：
4.8
作者：
Jonas, JC;Sharma, A;Weir, GC
通讯作者：
Weir, GC