Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
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DOI：
10.1086/422755
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发表时间：
2004-08-15
影响因子：
6.4
通讯作者：
Corey, L
中科院分区：
文献类型：
--
作者：
Posavad, CM;Wald, A;Corey, L
高效抗逆转录病毒疗法 (HAART) 对人类免疫缺陷病毒 (HIV) 1 型感染者单纯疱疹病毒 (HSV) 控制的效果尚不清楚。在 28 名接受 HAART 治疗和 49 名未经治疗的 HIV-1 和 HSV-2 感染受试者中，粘膜 HSV 脱落（HSV DNA 阳性天数中位数分别为 18% 和 29%；P = .08）和 HSV DNA 水平（中位数分别为 56,250 和 50,000 拷贝/mL；P = .20）相似。与未治疗受试者相比，接受治疗的受试者报告出现 HSV 病变的天数明显减少（分别为 2.8% 和 11.3%；P = .001）。因此，尽管HAART与HSV损伤天数减少有关，但在接受治疗的受试者中，粘膜HSV脱落和HSV-2重新激活仍然很常见。
The effect of highly active antiretroviral therapy ( HAART) on control of herpes simplex virus (HSV) in human immunodeficiency virus (HIV) type 1-infected subjects is not known. Among 28 HAART-treated and 49 untreated subjects with HIV-1 and HSV-2 infections, mucosal HSV shedding (median, 18% and 29% of days positive for HSV DNA, respectively; P = .08) and HSV DNA level ( median, 56,250 and 50,000 copies/mL, respectively; P = .20) were similar. Treated subjects reported significantly fewer days with HSV lesions, compared with untreated subjects (2.8% vs. 11.3% of days, respectively; P = .001). Thus, mucosal HSV shedding and HSV-2 reactivation were still frequent among treated subjects, even though HAART was associated with fewer days with HSV lesions.