Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort.
Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort.
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DOI：
10.1038/s41398-022-01808-1
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发表时间：
2022-02-01
影响因子：
6.8
通讯作者：
Hillard CJ
中科院分区：
文献类型：
--
作者：
deRoon-Cassini TA;Bergner CL;Chesney SA;Schumann NR;Lee TS;Brasel KJ;Hillard CJ
The endocannabinoid signaling system (ECSS) regulates fear and anxiety. While ECSS hypoactivity can contribute to symptoms of established post-traumatic stress disorder (PTSD), the role of the ECSS in PTSD development following trauma is unknown. A prospective, longitudinal cohort study of 170 individuals (47% non-Hispanic Caucasian and 70% male) treated at a level 1 trauma center for traumatic injury was carried out. PTSD symptom assessments and blood were obtained during hospitalization and at follow-up (6–8 months post injury). Serum concentrations of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) were determined at both time points and selected genetic polymorphisms in endocannabinoid genes, including rs324420 in fatty acid amide hydrolase, were assessed. For the entire sample, serum concentrations of AEA at hospitalization were significantly higher in those diagnosed with PTSD at follow-up (p = 0.030). Serum concentrations of 2-AG were significantly, positively correlated with PTSD symptom severity at follow-up only in minorities (p = 0.014). Minority participants (mostly Black/African American) also demonstrated significant, negative correlations between serum AEA concentrations and PTSD symptom severity both measured at hospitalization (p = 0.015). The A/A genotype at rs324420 was associated with significantly higher PTSD symptom severity (p = 0.025) and occurred exclusively in the Black participants. Collectively, these results are contrary to our hypothesis and find positive associations between circulating endocannabinoids and risk for PTSD. Minority status is an important modulator of the association between endocannabinoids and risk for PTSD, suggesting that the ECSS contributes to risk most significantly in these individuals and the contextual factors related to these findings should be further explored.
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DOI：
10.1523/jneurosci.0496-11.2011
发表时间：
2011-07-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill MN;McLaughlin RJ;Pan B;Fitzgerald ML;Roberts CJ;Lee TT;Karatsoreos IN;Mackie K;Viau V;Pickel VM;McEwen BS;Liu QS;Gorzalka BB;Hillard CJ
通讯作者：
Hillard CJ
影响因子：
3.4
作者：
Herrera-Escobar, Juan P.;Seshadri, Anupamaa J.;Nehra, Deepika
通讯作者：
Nehra, Deepika
影响因子：
10.6
作者：
Hariri, Ahmad R.;Gorka, Adam;Manuck, Stephen B.
通讯作者：
Manuck, Stephen B.
影响因子：
16.6
作者：
Feng, Q.;Vickers, K. C.;Wilke, R. A.
通讯作者：
Wilke, R. A.
影响因子：
13.6
作者：
deRoon-Cassini TA;Stollenwerk TM;Beatka M;Hillard CJ
通讯作者：
Hillard CJ