Vascular procedures that thermo-coagulate collagen reduce local platelet deposition and thrombus formation: laser and laser-thermal versus balloon angioplasty.
Vascular procedures that thermo-coagulate collagen reduce local platelet deposition and thrombus formation: laser and laser-thermal versus balloon angioplasty.
复制标题
热凝固胶原蛋白的血管手术可减少局部血小板沉积和血栓形成：激光和激光热血管成形术与球囊血管成形术。
DOI：
10.1002/lsm.10000
复制
发表时间：
2001
影响因子：
2.4
通讯作者：
Friedl,SE
中科院分区：
文献类型：
--
作者：
Abela,GS;Hage-Korban,EE;Tomaru,T;Barbeau,GR;Abela,OG;Friedl,SE
动脉壁基质暴露于血液导致血小板沉积，从而导致血栓形成。由于热改变组织基质，我们提出，加热减少血小板deposition.Study设计/材料和MethodsSixty动脉同种移植物（15只狗）安装在动静脉“分流”。干预措施包括球囊血管成形术（BA）、直接激光（LA）、激光热（LTA）和联合LTABA。111循环铟标记的血小板，测量放射性，并对同种移植物进行组织学处理。BA部位（13，853 ± 3，192 cpm/cm 2）的平均值± SE大于LA（7，038 ± 981）、LTA（5，294 ± 1，145）、LTABA（6，176 ± 1，571）和对照（1，826 ± 339），P< 0.05。电子显微镜检查显示LA、LTA和对照部位的血小板少于BA部位。BA蔓延的胶原蛋白的动脉腔，而热凝胶胶原蛋白，并将其限制到动脉mediates.ConclusionsHeating动脉和凝胶胶原蛋白在LA，LTA，或LTABA显着降低血栓形成。激光外科医学29：455-463，2001年。© 2001 Wiley利斯公司
Background and ObjectiveExposure of the arterial wall matrix to blood leads to platelet deposition resulting in thrombosis. Because heat alters tissue matrix we proposed that heating reduces platelet deposition.Study Design/Materials and MethodsSixty arterial homografts (15 dogs) were mounted in an arterio‐venous “shunt.” Interventions included balloon angioplasty (BA), direct laser (LA), laser‐thermal (LTA), and combined LTABA.111Indium‐labeled platelets were circulated, radio activity measured, and homografts processed for histology.ResultsRadioactivity count (mean ± SE) at BA sites (13,853 ± 3,192 cpm/cm2) was greater than LA (7,038 ± 981), LTA (5,294 ± 1,145), LTABA (6,176 ± 1,571), and control (1,826 ± 339),P< 0.05. Electron microscopy showed fewer platelets at LA, LTA, and control than BA sites. BA spread the collagen on the arterial lumen while heat gelled collagen and confined it to the arterial media.ConclusionsHeating the artery and gelling collagen during LA, LTA, or LTABA significantly reduced thrombogenicity. Lasers Surg. Med. 29:455–463, 2001. © 2001 Wiley‐Liss, Inc.