Human cytomegalovirus downregulates SLITRK6 expression through IE2.
Human cytomegalovirus downregulates SLITRK6 expression through IE2.
复制标题
人巨细胞病毒通过 IE2 下调 SLITRK6 表达。
DOI：
10.1007/s13365-016-0475-y
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发表时间：
2017
影响因子：
3.2
通讯作者：
Nakamura H.
中科院分区：
文献类型：
--
作者：
Liao H;Sato H;Chiba R;Kawai T;Nakabayashi K;Hata K;Akutsu H;Fujiwara S;Nakamura H.
Congenital human cytomegalovirus (HCMV) infection causes sensorineural hearing loss (SNHL) and other neurological disorders, although the neuropathogenesis of HCMV infection is not well understood. Here, we show that the expression ofSLITRK6, one of causative genes for hereditary SNHL, was robustly downregulated by HCMV infection in cultured neural cells. We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especially amino acid residue Gln548, has a critical role. These findings suggest that the downregulation ofSLITRK6expression by IE2 may have a role in HCMV-induced SNHL and other neurological disorders.
