Sendai virus F glycoprotein induces IL‐6 production in dendritic cells in a fusion‐independent manner
Sendai virus F glycoprotein induces IL‐6 production in dendritic cells in a fusion‐independent manner
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仙台病毒 F 糖蛋白以不依赖于融合的方式诱导树突状细胞产生 IL-6
DOI：
10.1016/j.febslet.2008.03.011
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发表时间：
2008
期刊：
影响因子：
3.5
通讯作者：
Y. Kaneda
中科院分区：
文献类型：
--
作者：
Hayato Suzuki;M. Kurooka;Y. Hiroaki;Y. Fujiyoshi;Y. Kaneda
我们以前报道过灭活的仙台病毒颗粒(日本包膜血凝病毒；HVJ-E)通过诱导树突状细胞(DC)产生IL-6而具有抗肿瘤作用。在本研究中，我们研究了HVJ-E的哪些成分可以诱导IL-6的产生。含有F0蛋白的HVJ-E对病毒包膜-细胞膜融合无活性，可促进IL-6的产生。含有F蛋白的重组脂质体刺激IL-6的产生。抗F蛋白抗体可抑制HVJ-E分泌IL-6。当F糖蛋白的碳水化合物链被移除时，HVJ-E失去刺激IL-6分泌的能力。这些结果表明，DC产生IL-6需要F糖蛋白。
We previously reported that inactivated Sendai virus particle (hemagglutinating virus of Japan envelope; HVJ-E) has anti-tumor effects by eliciting IL-6 production in dendritic cells (DCs). In the present study, we investigated which components of HVJ-E elicit IL-6 production. HVJ-E containing F0 protein inactive for virus envelope–cell membrane fusion enhanced IL-6 production. Reconstituted liposomes containing F protein stimulated IL-6 production. The antibody against F protein inhibited IL-6 secretion by HVJ-E. When carbohydrate chains of the F glycoprotein were removed, HVJ-E lost the ability to stimulate IL-6 secretion. These results suggest that F glycoprotein is required for IL-6 production in DCs.
影响因子：
6.4
作者：
López, CB;García-Sastre, A;Moran, TM
通讯作者：
Moran, TM