Hamycin: separation of toxicity and antifungal activity in mice.
Hamycin: separation of toxicity and antifungal activity in mice.
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Hamycin：在小鼠中分离毒性和抗真菌活性。
DOI：
10.1016/0024-3205(76)90081-3
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发表时间：
1976
期刊：
影响因子：
6.1
通讯作者：
C. Dave
中科院分区：
文献类型：
--
作者：
A. C. Parekh;C. Dave
Hamycin, either alone or in suspension as hamycin-cholesterol complex, was intravenously administered to mice in a single dose. Plasma antifungal activity at different time intervals and LD50at varying drug: cholesterol proportions were studied. Hamycin alone was eight-fold more toxic than the hamycin-cholesterol complex. While the antifungal activity of hamycin in plasma rapidly declined by first order kinetics, the activity of hamycin-cholesterol complex in plasma was maintained at the initial high level for a prolonged period and with a 12-fold increase in the apparent volume of distribution of the drug. The therapeutic implications of these findings are discussed.
