Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease
Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease
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DOI：
10.1007/s100720170039
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发表时间：
2001-02-01
影响因子：
3.3
通讯作者：
Pezzoli, G
中科院分区：
文献类型：
--
作者：
Antonini, A;De Notaris, R;Pezzoli, G
据报道，大部分帕金森病（PD）患者存在认知异常。通常认知变化是亚临床的，涉及额叶功能。在其他情况下，他们发展成完全痴呆症。功能性神经影像学可以帮助描述这些异常。我们研究了44例PD患者的脑灌注SPECT和示踪剂ECD，22例认知功能正常，22例有痴呆的临床和神经心理学体征。与21名健康对照组相比，痴呆PD患者在所有皮层区域，特别是颞叶和顶叶区域表现出显着的灌注减少;在非痴呆队列中，减少仅限于额叶区域。这些结果表明，脑灌注异常存在于PD患者。据推测，不同的病理机制下的灌注差异。
Cognitive abnormalities have been reported in a large percentage of patients with Parkinson's disease (PD). Often cognitive changes are sub-clinical and involve frontal lobe function. In other occasions they develop into full dementia. Functional neuroimaging may help characterize these abnormalities. We have studied brain perfusion with SPECT and the tracer ECD in 44 PD patients, 22 presenting with normal cognitive function and 22 with clinical and neuropsychological signs of dementia. Compared with 21 healthy controls, demented PD patients showed significant perfusion decrements in all cortical areas, particularly temporal and parietal regions; in the non-demented cohort reductions were limited to the frontal lobe area. These results suggest that brain perfusion abnormalities are present in PD patients. It is speculated that different pathological mechanisms underlie perfusion differences.