Water-soluble betamethasone-loaded poly(lactide-co-glycolide) hollow microparticles as a sustained release dosage form
Water-soluble betamethasone-loaded poly(lactide-co-glycolide) hollow microparticles as a sustained release dosage form
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DOI：
10.1080/0265204021000058447
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发表时间：
2003-05-01
影响因子：
3.9
通讯作者：
Phan, TT
中科院分区：
文献类型：
--
作者：
Chaw, CS;Yang, YY;Phan, TT
在这项研究中，贝替尼磷酸二钠负载微粒制备的持续释放使用聚（丙交酯-共-乙交酯）（PLGA）通过喷雾干燥和乳化溶剂蒸发/萃取技术。包封效率范围从59-80%，使用水在油在油（W/O/O）双乳液技术和超过90%的喷雾干燥方法获得。这与通过水包油包水（W/0/W）双乳液方法的制造相比是显著的改进，所述双乳液方法具有小于15%的包封效率。分别观察到PLGA 50/50和丙交酯含量较高的PLGA微粒的多相和双相释放曲线。使用W/O/O双重乳液技术制造的PLGA 50/50中空微粒提供了超过3周的磷酸二钠的持续释放。
In this study, betamethasone disodium phosphate-loaded microparticles were fabricated for sustained release using poly(lactide-co-glycolide) (PLGA) by spray drying and emulsion solvent evaporation/extraction techniques. Encapsulation efficiencies ranged from 59-80% using a water-in-oil-in-oil (W/O/O) double emulsion technique and more than 90% for a spray-drying method were obtained. This was a significant improvement compared to fabrication by a water-in-oil-in-water (W/O/W) double emulsion process, which had an encapsulation efficiency of less than 15%. Multiple-phase and biphasic release profiles were observed for microparticles of PLGA 50/50 and PLGA of higher lactide contents, respectively. The PLGA 50/50 hollow microparticles fabricated using the W/O/O double emulsion technique provided a sustained release of betamethasone disodium phosphate over 3 weeks.