Human leukocyte antigens B8-DRB1*03 in pediatric patients with nephropathia epidemica caused by Puumala hantavirus
Human leukocyte antigens B8-DRB1*03 in pediatric patients with nephropathia epidemica caused by Puumala hantavirus
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DOI：
10.1097/01.inf.0000141737.45047.99
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发表时间：
2004-10-01
影响因子：
3.6
通讯作者：
Uhari, M
中科院分区：
文献类型：
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作者：
Mustonen, J;Huttunen, NP;Uhari, M
在成人中，HLA单倍型B8-DRB1*03与由普马拉汉坦病毒引起的肾病流行的严重临床病程明显相关。我们调查了是否同样适用于儿科患者。39例患者中有20例（51%）存在这种HLA单倍型，显著高于芬兰人群（19%）。然而，HLA - B8-DRB1*03患者的临床表现与非HLA - B8-DRB1*03患者无显著差异。
In adults, HLA haplotype B8-DRB1*03 is clearly associated with a severe clinical course of nephropathia epidemica caused by Puumala hantavirus. We investigated whether the same applies in pediatric patients. This HLA haplotype was found in 20 of 39 (51%) of the patients, a significantly higher figure than in the Finnish population (19%). There were, however, no significant differences in the clinical picture between patients with and without HLA B8-DRB1*03.