The genomic basis of parasitism in the Strongyloides clade of nematodes.
The genomic basis of parasitism in the Strongyloides clade of nematodes.
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DOI：
10.1038/ng.3495
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发表时间：
2016-03
期刊：
影响因子：
30.8
通讯作者：
Berriman M
中科院分区：
文献类型：
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作者：
Hunt VL;Tsai IJ;Coghlan A;Reid AJ;Holroyd N;Foth BJ;Tracey A;Cotton JA;Stanley EJ;Beasley H;Bennett HM;Brooks K;Harsha B;Kajitani R;Kulkarni A;Harbecke D;Nagayasu E;Nichol S;Ogura Y;Quail MA;Randle N;Xia D;Brattig NW;Soblik H;Ribeiro DM;Sanchez-Flores A;Hayashi T;Itoh T;Denver DR;Grant W;Stoltzfus JD;Lok JB;Murayama H;Wastling J;Streit A;Kikuchi T;Viney M;Berriman M
土壤传播的线虫，包括类圆线虫，引起最普遍的被忽视的热带病之一。在这里，我们比较了四个类圆线虫属的基因组，包括人类病原体S stercoralis，以及它们的近缘种，即寄生寄生的寄生类（Parastrongyloides sp. suri）和自由生活的寄生类（Rhabditophanes sp）。一个显着的旁系同源扩展的关键基因家族-astacin样和SCP/TAPS编码基因家族-与寄生在这个分支的进化。利用独特的类圆线虫的生命周期，我们比较了其寄生和自由生活阶段的转录组，发现这些相同的基因在寄生阶段上调，强调了它们在线虫寄生中的作用。
Soil transmitted nematodes, including Strongyloides, cause one of the most prevalent Neglected Tropical Diseases. Here we compare the genomes of four Strongyloides spp., including the human pathogen S. stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp). A significant paralogous expansion of key gene families – astacin-like and SCP/TAPS coding gene families – is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle we compare the transcriptome of its parasitic and free-living stages and find that these same genes are upregulated in the parasitic stages, underscoring their role in nematode parasitism.