Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: Role of CD4(+) T cells in controlling larval development
Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: Role of CD4(+) T cells in controlling larval development
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DOI：
10.1128/iai.65.6.2457-2461.1997
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发表时间：
1997-06-01
影响因子：
3.1
通讯作者：
Hoerauf, A
中科院分区：
文献类型：
--
作者：
AlQaoud, KM;Taubert, A;Hoerauf, A
乙状扁丝虫是唯一一种在免疫功能正常的实验小鼠中从感染性幼虫发育成成虫的丝虫。被感染的 BALB/c 小鼠的 CD4(+) T 细胞耗竭导致蠕虫和微丝蚴的负担显着高于感染对照小鼠。 Th2 细胞因子、嗜酸性粒细胞增多和免疫球蛋白 E 在感染对照中强烈诱导，但在 CD4 耗尽的小鼠中减少。
Litomosoides sigmodontis is the only filaria which develops from infective larvae into adults in immunocompetent laboratory mice. Depletion of CD4(+) T cells from infected BALB/c mice resulted in worm and microfilarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongly induced in infected controls, were diminished in CD4-depleted mice.