Blood-brain barrier dysfunction and recovery
Blood-brain barrier dysfunction and recovery
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DOI：
10.1007/s00702-005-0375-4
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发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Gaillard, PJ
中科院分区：
文献类型：
--
作者：
de Boer, AG;Gaillard, PJ
在这篇文章中，我们讨论了血脑屏障(BBB)作为血和脑之间的接口的重要性。许多(大脑)疾病改变了血脑屏障的功能和完整性。这主要导致血脑屏障通透性增加。因此，我们研究了受炎症刺激影响的各种信号转导途径。自由基清除剂N-乙酰半胱氨酸对炎症刺激的血脑屏障有保护作用。在应用糖皮质激素后也发现了类似的结果。此外，还观察到糖皮质激素和干扰素-α、β可增加体外血脑屏障的紧密度，当两者一起使用时，可以看到增强作用。
In this paper we discuss the importance of the blood-brain barrier (BBB) as an interface between blood and brain. Many (brain) diseases change the functionality and integrity of the BBB. Mostly this results in increased BBB permeability. Therefore we have studied de various signal transduction routes that are influenced by inflammatory stimuli. The radical scavenger N-acetylcysteine was able to protect the BBB against inflammatory stimuli. Similar results were found following application of glucocorticoids. In addition, it was observed that glucocorticoids and interferon-alpha,beta increased the tightness of the in vitro BBB and when given together a potentiating effect was seen.