SUCCESSFUL TREATMENT OF ENTEROVIRUS-INFECTED MICE BY 2-(ALPHA-HYDROXYBENZYL)-BENZIMIDAZOLE AND GUANIDINE
SUCCESSFUL TREATMENT OF ENTEROVIRUS-INFECTED MICE BY 2-(ALPHA-HYDROXYBENZYL)-BENZIMIDAZOLE AND GUANIDINE
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DOI：
10.1084/jem.143.6.1367
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发表时间：
1976-01-01
影响因子：
15.3
通讯作者：
EGGERS, HJ
中科院分区：
文献类型：
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作者：
EGGERS, HJ
Echo病毒9型或柯萨奇A9病毒感染的新生小鼠通过与无毒浓度的HBB[2-(α-羟基苯并)-苯并咪唑]和胍联合治疗而免受瘫痪和死亡的保护。HBB单独对柯萨奇A9病毒感染的动物也有保护作用，但不能保护Echo病毒9感染的动物，而单独使用胍在这两种情况下都是无效的。保护是由于通过这些选择性抑制剂的抗病毒活性来抑制病毒复制。治疗必须在接种病毒后最迟48小时开始。如果在接种病毒时开始，三天的治疗就足够了。仅用1种化合物治疗后的保护失败并不是由于耐药病毒突变体的快速发展。被感染、治疗成功的小鼠可能会产生牢固的免疫力。
Echo virus 9- or Coxsackie A 9-infected newborn mice are protected from paralysis and death by combined treatment with nontoxic concentrations of HBB [2-(.alpha.-hydroxybenzyl)-benzimidazole] plus guanidine. HBB alone also protects Coxsackie A 9, but not echo virus 9-infected animals, whereas guanidine alone is ineffective in either case. Protection is due to inhibition of virus multiplication via the antiviral activity of these selective inhibitors. Treatment must be begun at the latest 48 h after virus inoculation. Three days of treatment are sufficient if started at the time of virus inoculation. Failure of protection after treatment with 1 compound alone is not due to rapid development of drug-resistant virus mutants. Infected, successfully treated mice may develop a solid immunity.