Nitrergic Mechanisms for Management of Recurrent Priapism.
Nitrergic Mechanisms for Management of Recurrent Priapism.
复制标题
治疗复发性阴茎异常勃起的氮能机制。
DOI：
10.1002/smrj.56
复制
发表时间：
2015
影响因子：
3.6
通讯作者：
Burnett,ArthurL
中科院分区：
文献类型：
--
作者：
Anele,UzomaA;Burnett,ArthurL
阴茎勃起症是一种与性兴趣或性欲无关的阴茎长时间勃起的症状。缺血型，包括其复发型，常伴有生理和心理并发症。因此，管理是至关重要的。治疗复发性阴茎勃起的理想方法应该解决其潜在的病理生理问题。目的回顾有关阴茎勃起障碍管理方法的文献，特别是与氮机制有关的文献。方法利用PubMed检索有关阴茎勃起障碍的病理生理及治疗方面的文献。主要观察指标：有关阴茎勃起的分子病理生理机制的出版物。结果阴功机制在阴茎勃起的分子病理生理中起着重要作用。磷酸二酯酶5型抑制剂是一种有效的治疗选择，具有减轻这些潜在的氮能紊乱的能力。一些额外的信号通路已经被发现在阴茎勃起的分子病理生理中发挥作用，并且也与这些氮能机制有关。结论对阴茎勃起的分子病理生理认识的不断深入，有助于发现新的潜在靶点。未来可能会出现几种基于机制的治疗方法。
IntroductionPriapism is a condition involving prolonged penile erection unrelated to sexual interest or desire. The ischemic type, including its recurrent variant, is often associated with both physical and psychological complications. As such, management is of critical importance. Ideal therapies for recurrent priapism should address its underlying pathophysiology.AimTo review the available literature on priapism management approaches particularly related to nitrergic mechanisms.MethodsA literature review of the pathophysiology and management of priapism was performed using PubMed.Main Outcome MeasurePublications pertaining to mechanisms of the molecular pathophysiology of priapism.ResultsNitrergic mechanisms are characterized as major players in the molecular pathophysiology of priapism. Phosphodiesterase type 5 inhibitors represent an available therapeutic option with demonstrated ability in attenuating these underlying nitrergic derangements. Several additional signaling pathways have been found to play a role in the molecular pathophysiology of priapism and have also been associated with these nitrergic mechanisms.ConclusionAn increasing understanding of the molecular pathophysiology of priapism has led to the discovery of new potential targets. Several mechanism-based therapeutic approaches may become available in the future.