Clinical and Infection Prevention Applications of Severe Acute Respiratory Syndrome Coronavirus 2 Genotyping: An Infectious Diseases Society of America/American Society for Microbiology Consensus Review Document.
Clinical and Infection Prevention Applications of Severe Acute Respiratory Syndrome Coronavirus 2 Genotyping: An Infectious Diseases Society of America/American Society for Microbiology Consensus Review Document.
复制标题
DOI：
10.1093/cid/ciab761
复制
发表时间：
2022-04-28
期刊：
影响因子：
--
通讯作者：
Lee FM
中科院分区：
文献类型：
--
作者：
Greninger AL;Dien Bard J;Colgrove RC;Graf EH;Hanson KE;Hayden MK;Humphries RM;Lowe CF;Miller MB;Pillai DR;Rhoads DD;Yao JD;Lee FM
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进入了一个成熟的病原体基因组学世界，在撰写本文时已测序了超过200万个基因组。影响疫苗和治疗效果的更多可传播变异的出现引起了人们对SARS-CoV-2进化的广泛兴趣。临床医生也渴望利用SARS-CoV-2基因分型提供的信息，而不仅仅是为了监测目的。在这里，我们回顾了SARS-CoV-2基因分型在临床护理中的潜在作用。该综述涵盖了SARS-CoV-2基因分型的临床用例、SARS-CoV-2基因分型方法、检测验证和监管要求、实验室临床报告以及临床SARS-CoV-2测序中出现的问题。虽然SARS-CoV-2基因分型的临床应用目前有限，但随着疫苗和治疗效果数据的不断涌现，快速的技术变革沿着以及真实的时间内解释变异体的能力不断增强，预示着SARS-CoV-2基因分型在临床护理中的作用越来越大。本文综述了SARS-CoV-2基因分型在临床护理中的潜在作用。快速的技术变革沿着实时解释变异的能力不断增强，预示着SARS-CoV-2基因分型在临床护理中的作用越来越大。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged into a world of maturing pathogen genomics, with >2 million genomes sequenced at this writing. The rise of more transmissible variants of concern that affect vaccine and therapeutic effectiveness has led to widespread interest in SARS-CoV-2 evolution. Clinicians are also eager to take advantage of the information provided by SARS-CoV-2 genotyping beyond surveillance purposes. Here, we review the potential role of SARS-CoV-2 genotyping in clinical care. The review covers clinical use cases for SARS-CoV-2 genotyping, methods of SARS-CoV-2 genotyping, assay validation and regulatory requirements, clinical reporting for laboratories, and emerging issues in clinical SARS-CoV-2 sequencing. While clinical uses of SARS-CoV-2 genotyping are currently limited, rapid technological change along with a growing ability to interpret variants in real time foretell a growing role for SARS-CoV-2 genotyping in clinical care as continuing data emerge on vaccine and therapeutic efficacy. This article reviews the potential role of SARS-CoV-2 genotyping in clinical care. Rapid technological change along with a growing ability to interpret variants in real-time foretell a growing role for SARS-CoV-2 genotyping in clinical care.
登录
查看更多内容
影响因子：
3.7
作者：
Bhoyar RC;Jain A;Sehgal P;Divakar MK;Sharma D;Imran M;Jolly B;Ranjan G;Rophina M;Sharma S;Siwach S;Pandhare K;Sahoo S;Sahoo M;Nayak A;Mohanty JN;Das J;Bhandari S;Mathur SK;Kumar A;Sahlot R;Rojarani P;Lakshmi JV;Surekha A;Sekhar PC;Mahajan S;Masih S;Singh P;Kumar V;Jose B;Mahajan V;Gupta V;Gupta R;Arumugam P;Singh A;Nandy A;P V R;Jha RM;Kumari A;Gandotra S;Rao V;Faruq M;Kumar S;Reshma G B;Varma G N;Roy SS;Sengupta A;Chattopadhyay S;Singhal K;Pradhan S;Jha D;Naushin S;Wadhwa S;Tyagi N;Poojary M;Scaria V;Sivasubbu S
通讯作者：
Sivasubbu S
影响因子：
5.3
作者：
Duchene, Sebastian;Featherstone, Leo;Baele, Guy
通讯作者：
Baele, Guy
DOI：
10.1016/s1473-3099(20)30562-4
发表时间：
2020-11
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Meredith LW;Hamilton WL;Warne B;Houldcroft CJ;Hosmillo M;Jahun AS;Curran MD;Parmar S;Caller LG;Caddy SL;Khokhar FA;Yakovleva A;Hall G;Feltwell T;Forrest S;Sridhar S;Weekes MP;Baker S;Brown N;Moore E;Popay A;Roddick I;Reacher M;Gouliouris T;Peacock SJ;Dougan G;Török ME;Goodfellow I
通讯作者：
Goodfellow I
影响因子：
3.5
作者：
Alessandrini, Federica;Caucci, Sara;Menzo, Stefano
通讯作者：
Menzo, Stefano
影响因子：
56.3
作者：
Sikkema, Reina S.;Pas, Suzan D.;Koopmans, Marion P. G.
通讯作者：
Koopmans, Marion P. G.