Online isotope analysis of 37Cl/35Cl universally applied for semi-volatile organic compounds using GC-MC-ICPMS
Online isotope analysis of 37Cl/35Cl universally applied for semi-volatile organic compounds using GC-MC-ICPMS
复制标题
使用 GC-MC-ICPMS 对普遍应用于半挥发性有机化合物的 37Cl/35Cl 进行在线同位素分析
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
M. Gehre
中科院分区：
文献类型：
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作者：
J. Renpenning;Axel Horst;Matthias Schmidt;M. Gehre
有机化合物的稳定氯同位素分析可能适用于法医学和环境分析的各个领域，以调查这些物质在环境中的去向，但由于现有的线下和在线技术的适用性有限，这项技术的更广泛使用仍然受到阻碍。在以前的研究中，我们提出了一种利用多收集器电感耦合等离子体质谱(GC-MC-ICPMS)接口的气相色谱-多收集器电感耦合等离子体质谱(GC-MC-ICPMS)分析挥发性有机物(包括氯代甲烷、乙烷和乙烯)的化合物特定氯同位素的方法。在目前的研究中，我们进一步修改了设置，以扩大分析范围，使其适用于沸点高达350°C的半挥发性有机物质。修改后的方法通过使用离线表征的内部参考物质(如氯乙烯、氯乙酸和六氯环己烯)进行评估。此外，还对各种氯代苯、氯代酚、十氯酮、二氯二苯基三氯乙烷(DDT)及其相关衍生物进行了分析。对于单一化合物的分析精度(1σ)通常优于±0.2mur，对于混合物的特定化合物的分析精度通常优于±0.3mur。与可用的离线值相比，获得的精度在±0.2微米以内。同位素检测下限可以显著提高一个数量级(柱上250pmolCl，对应于∼10ngCl)，并且优于其他在线技术状态的方法。所展示的方法允许对几乎所有与GC兼容的有机物进行化合物特定的稳定氯同位素分析，具有通用性、高精度和灵敏度。
Stable chlorine isotope analysis of organic compounds is potentially applicable in various fields in forensics and environmental analytics to investigate the fate of these substances in the environment, but a wider use of this technique is still hampered by the limited applicability of available offline and online techniques. In a previous study we presented a method for compound-specific chlorine isotope analysis of volatile organics including chlorinated methanes, ethanes and ethenes using gas chromatography interfaced with multiple-collector inductively coupled plasma mass spectrometry (GC-MC-ICPMS). In the current study we modified further the setup in order to extend the range of analytes towards semi-volatile organic substances with boiling points of up to 350 °C. The modified method was evaluated by using offline characterized in-house reference materials, such as chloroethenes, chloroacetic acid and hexachlorocyclohexenes. Additionally, analysis of various chlorinated benzenes, chlorinated phenols, chlordecone, dichlorodiphenyltrichloroethane (DDT) and related derivatives was demonstrated. The analytical precision (1σ) was usually better than ±0.2 mUr for single compound and ±0.3 mUr for compound-specific analysis of mixtures. Achieved accuracy was within ±0.2 mUr compared to available offline values. The isotopic detection limit could be significantly improved by one order of magnitude (250 pmol Cl on column, corresponding to ∼10 ng Cl) and is superior to other online state of the art approaches. The demonstrated method allows for the compound-specific stable chlorine isotope analysis of virtually all GC-compatible organics with versatility, high accuracy, and sensitivity.