Experience enhances certainty about olfactory stimuli under bulbar cholinergic control
Experience enhances certainty about olfactory stimuli under bulbar cholinergic control
复制标题
DOI：
10.1101/lm.051854.120
复制
发表时间：
2020-10-01
影响因子：
2
通讯作者：
Linster, Christiane
中科院分区：
文献类型：
--
作者：
Cho, Christina;Linster, Christiane
我们提出的证据表明，经验和早期感觉网络中的胆碱能调节相互作用，以提高嗅觉刺激的确定性。我们提出的数据与现有的关于乙酰胆碱功能作用的理论观点一致，但强调了早期感觉网络和皮质网络的重要性。我们在老鼠身上使用了一个简单的行为范式，它允许我们通过对条件和新刺激的反应幅度来测量刺激的确定性。我们的结论是，额外的学习增加了确定性，这种关系的斜率可以通过激活嗅球中的毒蕈碱胆碱能受体来调节。
We present evidence that experience and cholinergic modulation in an early sensory network interact to improve certainty about olfactory stimuli. The data we present are in agreement with existing theoretical ideas about the functional role of acetylcholine but highlight the importance of early sensory networks in addition to cortical networks. We use a simple behavioral paradigm in mice which allows us to measure certainty about a stimulus via the response amplitude to a condition and novel stimuli. We conclude that additional learning increases certainty and that the slope of this relationship can be modulated by activation of muscarinic cholinergic receptors in the olfactory bulb.