Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research.
Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research.
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DOI：
10.1097/wnp.0000000000000230
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Critical Care EEG Monitoring Research Consortium (CCEMRC)
中科院分区：
文献类型：
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作者：
Lee JW;LaRoche S;Choi H;Rodriguez Ruiz AA;Fertig E;Politsky JM;Herman ST;Loddenkemper T;Sansevere AJ;Korb PJ;Abend NS;Goldstein JL;Sinha SR;Dombrowski KE;Ritzl EK;Westover MB;Gavvala JR;Gerard EE;Schmitt SE;Szaflarski JP;Ding K;Haas KF;Buchsbaum R;Hirsch LJ;Wusthoff CJ;Hopp JL;Hahn CD;Critical Care EEG Monitoring Research Consortium (CCEMRC)
连续重症监护脑电图（cEEG）监测的使用迅速扩大，并通过重症监护脑电图监测研究联盟进行多中心研究，因此需要建立协作数据共享机制和存储库。作者描述了一个研究数据库的发展，该数据库纳入了美国临床神经生理学学会重症监护EEG监测的标准化术语。该数据库包括灵活的报告生成工具，允许日常临床使用。将关键临床和研究变量纳入Microsoft Access数据库。为了评估其在多中心研究数据收集中的效用，作者进行了一项21个中心的可行性研究，其中每个中心输入了12名连续重症监护室监测患者的数据。为了评估其作为临床报告生成工具的实用性，三个大容量中心使用其生成每日临床重症监护EEG报告。多中心可行性研究共入组了280例受试者。记录持续时间（中位数，25.5小时）在中心之间存在显著差异。癫痫发作（17.6%）、周期性/节律性放电（35.7%）和发作间期癫痫样放电（11.8%）的发生率与既往研究相似。该数据库被3家临床试验机构用作临床报告工具，共输入了3，144例独特患者，涵盖6，665个记录日。重症监护EEG监测研究联盟数据库已成功开发和实施，具有作为协作研究平台和临床报告工具的双重作用。它现在可供公众下载，用作临床数据存储库和报告生成工具。
The rapid expansion of the use of continuous critical care electroencephalogram (cEEG) monitoring and resulting multicenter research studies through the Critical Care EEG Monitoring Research Consortium has created the need for a collaborative data sharing mechanism and repository. The authors describe the development of a research database incorporating the American Clinical Neurophysiology Society standardized terminology for critical care EEG monitoring. The database includes flexible report generation tools that allow for daily clinical use. Key clinical and research variables were incorporated into a Microsoft Access database. To assess its utility for multicenter research data collection, the authors performed a 21-center feasibility study in which each center entered data from 12 consecutive intensive care unit monitoring patients. To assess its utility as a clinical report generating tool, three large volume centers used it to generate daily clinical critical care EEG reports. A total of 280 subjects were enrolled in the multicenter feasibility study. The duration of recording (median, 25.5 hours) varied significantly between the centers. The incidence of seizure (17.6%), periodic/rhythmic discharges (35.7%), and interictal epileptiform discharges (11.8%) was similar to previous studies. The database was used as a clinical reporting tool by 3 centers that entered a total of 3,144 unique patients covering 6,665 recording days. The Critical Care EEG Monitoring Research Consortium database has been successfully developed and implemented with a dual role as a collaborative research platform and a clinical reporting tool. It is now available for public download to be used as a clinical data repository and report generating tool.