INFECTIOUS BURSAL DISEASE VIRUS VARIANT FROM COMMERCIAL LEGHORN PULLETS
INFECTIOUS BURSAL DISEASE VIRUS VARIANT FROM COMMERCIAL LEGHORN PULLETS
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DOI：
10.2307/1591345
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发表时间：
1990-01-01
期刊：
影响因子：
1.4
通讯作者：
JACKSON, C
中科院分区：
文献类型：
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作者：
ISMAIL, NM;SAIF, YM;JACKSON, C
从怀疑患有传染性法氏囊病 (IBD) 的 39 至 43 日龄商品来航小母鸡中分离出传染性法氏囊病病毒 (IBDV)。这些鸡在 28 日龄和 35 日龄时接种了商业 IBDV 活疫苗。使用无特定病原体 (SPF) 鸡和 BGM-70 建立的细胞系回收了分离设计的 IN。使用 SPF 鸡接种由问题鸡群中使用的疫苗株制成的活性疫苗或标准型疫苗进行的实验研究表明，对 IN 分离株没有保护作用。然而，两种变体和另一种标准型疫苗诱导了针对 IN 分离株的保护。交叉中和试验表明，IN 分离株在抗原性上与商业疫苗株不同，并且与最近从肉鸡中分离出的 IBDV 变异株相关。据我们所知，这是从美国商业蛋鸡中发现的 IBDV 变种的第一份报告。
An infectious bursal disease virus (IBDV) was isolated from 39-to-43-day-old commerical leghorn pullets suspected of having infectious bursal disease (IBD). These chickens had been vaccinated with a commerical live IBDV vaccine at 28 and 35 days of age. An isolated designed IN was recovered using specific-pathogen-free (SPF) chickens and the BGM-70 established cell line. Experimental studies using SPF chickens vaccinated with either in activated vaccines made from the vaccine strain used in the problem flock or a standard-type vaccine indicated no protection against the IN isolate. However, two variants and another standard-type vaccine induced protection against the IN isolate. Cross-neutralization tests indicated that the IN isolate differed antigenically from commerical vaccine strains and was related to the variant IBDV strains recently isolated from broilers. To our knowledge, this is the first report of a variant IBDV recovered from commercial layer chickens in the United States.