Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance.
Current understanding of the mechanisms for clearance of apoptotic cells-a fine balance.
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DOI：
10.4137/jcd.s11037
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Devitt A
中科院分区：
文献类型：
--
作者：
Hawkins LA;Devitt A
细胞凋亡是多细胞生物体去除不需要的细胞的一种重要的细胞死亡机制。它的高潮是通过邻近或招募的活细胞快速、有控制地去除细胞尸体。虽然许多介导尸体清除的分子机制是先天免疫系统的组成部分，但凋亡细胞的清除是一种抗炎过程。细胞死亡的控制依赖于竞争性促凋亡和抗凋亡信号。现在有证据表明，竞争信号的类似平衡是有效去除细胞的核心，通过所谓的“吃我”和“不吃我”信号。竞争信号对于吞噬细胞向细胞死亡部位的受控募集也很重要。因此，吞噬细胞在细胞死亡部位的募集可能是细胞死亡和炎症消退或不适当传播的基础。本文强调了我们的理解机制介导的死亡细胞的清除，并讨论了控制吞噬细胞迁移的机制，以及如何不适当的控制可能会促进重要的病理。
Apoptosis is an important cell death mechanism by which multicellular organisms remove unwanted cells. It culminates in a rapid, controlled removal of cell corpses by neighboring or recruited viable cells. Whilst many of the molecular mechanisms that mediate corpse clearance are components of the innate immune system, clearance of apoptotic cells is an anti-inflammatory process. Control of cell death is dependent on competing pro-apoptotic and anti-apoptotic signals. Evidence now suggests a similar balance of competing signals is central to the effective removal of cells, through so called ‘eat me’ and ‘don’t eat me’ signals. Competing signals are also important for the controlled recruitment of phagocytes to sites of cell death. Consequently recruitment of phagocytes to and from sites of cell death can underlie the resolution or inappropriate propagation of cell death and inflammation. This article highlights our understanding of mechanisms mediating clearance of dying cells and discusses those mechanisms controlling phagocyte migration and how inappropriate control may promote important pathologies.