"Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation.
"Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation.
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DOI：
10.1055/s-0035-1556049
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发表时间：
2015-10
影响因子：
5.7
通讯作者：
Versteeg HH
中科院分区：
文献类型：
--
作者：
Bogdanov VY;Versteeg HH
组织因子（TF）是血液凝固的主要触发因子，对正常止血至关重要。在过去的20年里，TF的血管内水平和活性的升高越来越被认为是一个显著促进静脉和动脉血栓形成的实体。已经描述了循环中的各种形式的TF蛋白，并提出是血栓形成的。除了与细胞和血管壁相关的TF外，几种形式的非细胞相关TF在血浆中循环，并可能作为血栓形成的致病因素。目前，关于TF形成的程度、血管环境和/或导致血栓形成和扩散的机制，还没有明确的共识。在这里，我们总结了现有的范式和最近，有时范式转移的研究结果阐明了结构，机制和病理生理学特征的血浆传播的TF。
Tissue factor (TF), the main trigger of blood coagulation, is essential for normal hemostasis. Over the past 20 years, heightened intravascular levels and activity of TF have been increasingly perceived as an entity that significantly contributes to venous as well as arterial thrombosis. Various forms of the TF protein in the circulation have been described and proposed to be thrombogenic. Aside from cell and vessel wall-associated TF, several forms of non–cell-associated TF circulate in plasma and may serve as a causative factor in thrombosis. At the present time, no firm consensus exists regarding the extent, the vascular setting(s), and/or the mechanisms by which such TF forms contribute to thrombus initiation and propagation. Here, we summarize the existing paradigms and recent, sometimes paradigm-shifting findings elucidating the structural, mechanistic, and pathophysiological characteristics of plasma-borne TF.