Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use.
Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use.
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DOI：
10.1016/j.cmi.2020.02.028
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发表时间：
2020-03
期刊：
影响因子：
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通讯作者：
J. Pollock;Alison S. Low;Rebecca E. McHugh;A. Muwonge;M. Stevens;A. Corbishley;D. Gally
中科院分区：
文献类型：
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作者：
J. Pollock;Alison S. Low;Rebecca E. McHugh;A. Muwonge;M. Stevens;A. Corbishley;D. Gally
背景这篇综述是同一健康抗菌药物耐药性国际会议的后续（ICOHAR 2019），其中讨论了在人类，动物和环境之间的界面上提高对抗菌素耐药性的基本理解和管理的策略。注意到基因组技术的进步是如何帮助其发展和实现更有针对性地使用抗菌剂的。来源关于使用微生物群调节，牲畜育种和基因编辑，疫苗接种，抗菌药物是疾病控制的核心，但由于可传播的抗菌素耐药性的上升，减少其使用至关重要。本文综述了抗菌替代品的背景下，提高认识的基本主机病原体和微生物群的相互作用，使用基因组tools.ImplicationsHost和微生物基因组学和其他新技术发挥了重要作用，在制定疾病控制策略，健康的动物和人类，从而减少我们对抗菌药物的依赖。
BackgroundThis review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed.ObjectiveThis review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials.SourcesKey articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, antivirulence strategies and bacteriophage therapy are discussed.ContentAntimicrobials are central for disease control, but reducing their use is paramount as a result of the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host–pathogen and microbiota interactions using genomic tools.ImplicationsHost and microbial genomics and other novel technologies play an important role in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.