Femoral blood concentrations of flualprazolam in 33 postmortem cases
Femoral blood concentrations of flualprazolam in 33 postmortem cases
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DOI：
10.1016/j.forsciint.2019.110101
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发表时间：
2020-02-01
影响因子：
2.2
通讯作者：
Vikingsson, Svante
中科院分区：
文献类型：
--
作者：
Kriikku, Pirkko;Rasanen, Ilpo;Vikingsson, Svante
氟阿普唑仑是一种新型的苯二氮卓类药物，结构上与阿普唑仑、氟溴唑仑和三唑仑相关。在过去几年中，在瑞典和芬兰的缉获和法医案件中经常发现这种物质。然而，由于缺乏已发表的该药的血药浓度，因此在评估其与死亡原因的相关性时存在困难。开发并验证了一种用于测定死后血液中氟阿普唑仑的定量方法，随后用于分析瑞典和芬兰33例先前筛查为氟吡唑仑检测阳性的死亡病例的样本。研究中的大多数病例为意外死亡（61%）或自杀（18%）。氟阿普唑仑浓度的中位数（范围）为18.0（3.0-68）ng/g。大部分死者为男性（82%），年龄中位数为30岁。瑞典病例的中位年龄（35岁）显著高于芬兰病例（23岁）（p < 0.05）。多种药物使用，特别是氟阿普唑仑和阿片类药物的合并使用在研究人群中非常常见。大多数氟吡唑仑阳性的病例是药物致死性中毒（N = 23），在13例病例中，氟吡唑仑与死因有关。结合两个国家的资源，所有死后毒理学集中在一起，对氟吡唑仑的毒理学提供了更全面的了解。需要对氟吡唑仑等新型精神活性物质进行研究，以便能够为药物管理和潜在使用者提供有关这些新物质风险的科学证据。(C)2019 Elsevier B. V.版权所有。
Flualprazolam is a novel designer benzodiazepine, structurally related to alprazolam, flubromazolam and triazolam. In the last couple of years, it has been frequently detected in seizures and in forensic cases in Sweden and Finland. However, there is a lack of published blood concentrations for the drug, which presents difficulties when assessing its relevance for the cause of death.A quantitative method for the determination of flualprazolam in post-mortem blood was developed and validated, and subsequently used to analyse samples from 33 deaths previously screened as testing positive for flualprazolam in Sweden and Finland.Most of the cases in the study were accidental deaths (61 %) or suicides (18 %). The median (range) flualprazolam concentration was 18.0 (3.0-68) ng/g. The majority of the deceased were male (82 %) and the median age was 30 years. The median age in the Swedish cases was significantly higher (35 years) than in the Finnish cases (23 years) (p < 0.05). Poly-drug use and particularly the concomitant use of flualprazolam and opioids were very common in the study population. Most of the cases that were positive for flualprazolam were fatal poisonings by a drug (N = 23), and in 13 cases, flualprazolam was implicated in the cause of death.Combining the resources of two countries in which all post-mortem toxicology is centralised provided a more comprehensive insight into the toxicology of flualprazolam. Research on novel psychoactive substances, such as flualprazolam, is required in order to be able to provide scientific evidence on the risks of these new substances for drug administration and potential users. (C) 2019 Elsevier B.V. All rights reserved.