New MRI Biomarkers Advance the Characterization of Parkinson Disease.
New MRI Biomarkers Advance the Characterization of Parkinson Disease.
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DOI：
10.17925/enr.2013.08.02.85
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发表时间：
2013
影响因子：
--
通讯作者：
Corkin S
中科院分区：
文献类型：
--
作者：
Ziegler DA;Corkin S
特发性帕金森病（PD）的病理生理学传统上被表征为黑质变性，但仔细检查广泛的神经病理学改变表明神经元脆弱性的个体差异。PD疾病进展研究的一个主要限制是常规MRI技术对受疾病影响的结构提供相对较差的对比度，因此通常不用于实验或临床研究。在这里，我们回顾了目前的状态，结构MRI适用于PD大脑的分析。我们还描述了一种新的多光谱MRI方法，提供了改善的对比度的黑质和基底前脑，我们最近用它来显示，这些结构显示不同的轨迹的体积损失在疾病的早期。
The pathophysiology of idiopathic Parkinson disease (PD) is traditionally characterized as substantia nigra degeneration, but careful examination of the widespread neuropathological changes suggests individual differences in neuronal vulnerability. A major limitation to studies of disease progression in PD has been that conventional MRI techniques provide relatively poor contrast for the structures that are affected by the disease, and thus are not typically used in experimental or clinical studies. Here, we review the current state of structural MRI as applied to the analysis of the PD brain. We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories of volume loss early in the disease.