Pregnancy is a model for tumors, not transplantation
Pregnancy is a model for tumors, not transplantation
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DOI：
10.1111/aji.12524
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发表时间：
2016-07-01
影响因子：
3.6
通讯作者：
Gilman-Sachs, Alice
中科院分区：
文献类型：
--
作者：
Beaman, Kenneth D.;Jaiswal, Mukesh K.;Gilman-Sachs, Alice
自 Peter Medawar 提出以下问题以来，已经过去了近 65 年：“怀孕的母亲如何在数周或数月内设法在自身内部滋养一个抗原性异物的胎儿。”现在，对生殖免疫学的了解表明，胎盘中的 HLA 抗原是非经典的，不会引起排斥反应。在胎盘和肿瘤中，50％或更多的细胞是免疫系统的细胞，曾经被认为已准备好杀死肿瘤或“胎儿移植物”，但这些细胞不是潜在的杀手，而是促进肿瘤或胎盘的生长。我们相信这些细胞的存在是为了创造一个促进胎盘或肿瘤生长的环境。通过检查胎盘和肿瘤免疫细胞的相似性，可以设计出消除肿瘤的新机制。
Nearly 65 years have passed since Peter Medawar posed the following question: "How does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body." Now, understanding of reproductive immunology has demonstrated that the HLA antigens in the placenta are non-classical and do not induce rejection. In the placenta and in tumors, 50% or more of the cells are cells of the immune system and were once thought to be primed and ready for killing tumors or the "fetal transplant" but these cells are not potential killers but abet the growth of either the tumor or the placenta. We believe that these cells are there to create an environment, which enhances either placental or tumor growth. By examining the similarities of the placenta's and tumor's immune cells, novel mechanisms to cause tumors to be eliminated can be devised.