Biochemical and immunohistochemical studies on collagenase in resorbing bone in tissue culture. A novel hypothesis for the mechanism of bone resorption.
Biochemical and immunohistochemical studies on collagenase in resorbing bone in tissue culture. A novel hypothesis for the mechanism of bone resorption.
复制标题
胶原酶在组织培养中吸收骨的生化和免疫组织化学研究。
DOI：
10.1111/j.1600-0765.1982.tb02046.x
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发表时间：
1982
影响因子：
3.5
通讯作者：
Sakamoto,M
中科院分区：
文献类型：
--
作者：
Sakamoto,S;Sakamoto,M
越来越多的证据表明，骨吸收是一种动态且复杂的连锁反应，不仅涉及破骨细胞，还涉及各种其他细胞类型。学者们在此报告了组织培养中骨吸收过程中胶原酶产生和定位的生化和免疫组织化学研究，并提出了骨吸收机制的新假设。发现几乎所有从组织培养基中分离的骨胶原酶都是潜在胶原酶的形式。
An increasing body of evidence suggests that bone resorption is a dynamic and complex chain reaction which involves not only osteoclasts but also various other cell types. Scholars report here biochemical and immunohistochemical studies on collagenase production and localization in resorbing bone in tissue culture and propose a novel hypothesis for the mechanism of bone resorption. Almost all of the bone collagenase isolated from the tissue culture medium was found to be in the form of latent collagenase.