Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy
Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy
复制标题
纳米材料介导的cGAS-STING信号通路调节用于增强癌症免疫治疗
DOI：
10.1016/j.actbio.2024.01.008
复制
发表时间：
2024-02-15
影响因子：
9.7
通讯作者：
Shi，Kai
中科院分区：
文献类型：
--
作者：
Wang，Yaxin;Liu，Yunmeng;Shi，Kai
尽管目前免疫治疗前景看好，但许多癌症患者仍然面临着免疫应答率低等挑战，导致现有治疗方法的临床疗效不令人满意。迫切需要将新兴的生物医学发现与传统疗法的创新结合起来。CGAS-STING信号通路的调节是一条重要的先天免疫治疗途径，在先天免疫和病毒防御中起着至关重要的DNA传感机制的作用。作为癌症治疗的一个新兴靶点，它已经引起了越来越多的关注。由于纳米材料具有大的比表面积和高效的渗透性等特殊的物理化学性质，纳米技术的最新进展导致纳米材料在癌症免疫治疗中的重要应用。鉴于cGAS-STING激活推动的肿瘤免疫治疗的快速发展，本文综述了利用纳米材料调控这一信号通路的最新研究进展。本文在介绍cGAS-STING信号通路主要激活机制的基础上，重点介绍了纳米材料在介导激动剂参与并有效激活这一信号通路方面的研究进展。此外，还讨论了基于cGAS-STING信号通路激活的组合纳米疗法，包括将纳米激动剂与化疗、放射治疗以及肿瘤靶向治疗中的其他免疫调节相结合的新策略。意义陈述鉴于cGAS/STING激活驱动的癌症免疫治疗的快速发展，本研究综述了利用纳米材料调节这一信号通路的最新研究进展。本文在介绍cGAS刺激物的关键成分及其激活机制的基础上，重点介绍了能够介导相应激动剂并有效激活这一信号通路的纳米材料。此外，还讨论了基于激活cGAS-STING信号通路的组合纳米疗法，包括将纳米配方激动剂与化疗、放射治疗以及癌症治疗中的免疫调节相结合的新兴策略。
Despite the current promise of immunotherapy, many cancer patients still suffer from challenges such as poor immune response rates, resulting in unsatisfactory clinical efficacy of existing therapies. There is an urgent need to combine emerging biomedical discoveries and innovations in traditional therapies. Modulation of the cGAS-STING signalling pathway represents an important innate immunotherapy pathway that serves as a crucial DNA sensing mechanism in innate immunity and viral defense. It has attracted increasing attention as an emerging target for cancer therapy. The recent advancements in nanotechnology have led to the significant utilization of nanomaterials in cancer immunotherapy, owing to their exceptional physicochemical properties such as large specific surface area and efficient permeability. Given the rapid development of cancer immunotherapy driven by the cGAS-STING activation, this study reviews the latest research progress in employing nanomaterials to modulate this signaling pathway. Based on the introduction of the main activation mechanisms of cGAS-STING pathway, this review focuses on nanomaterials that mediate the agonists involved and effectively activate this signaling pathway. In addition, combination nanotherapeutics based on the activation of the cGAS-STING signaling pathway are also discussed, including emerging strategies combining nanoformulated agonists with chemotherapy, radiotherapy as well as other immunomodulation in tumor targeting therapy.Statement of SignificanceGiven the rapid development of cancer immunotherapy driven by the cGAS / STING activation, this study reviews the latest research advances in the use of nanomaterials to modulate this signaling pathway. Based on the introduction of key cGAS-STING components and their activation mechanisms, this review focuses on nanomaterials that can mediate the corresponding agonists and effectively activate this signaling pathway. In addition, combination nanotherapies based on the activation of the cGAS-STING signaling pathway are also discussed, including emerging strategies combining nanoformulated agonists with chemotherapy, radiotherapy as well as immunomodulation in cancer therapy,.