HBx Protein Contributes to Liver Carcinogenesis by H3K4me3 Modification Through Stabilizing WD Repeat Domain 5 Protein
HBx Protein Contributes to Liver Carcinogenesis by H3K4me3 Modification Through Stabilizing WD Repeat Domain 5 Protein
复制标题
HBx 蛋白通过稳定 WD 重复结构域 5 蛋白进行 H3K4me3 修饰，从而促进肝癌发生
DOI：
10.1002/hep.30947
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发表时间：
2020-01-26
期刊：
影响因子：
13.5
通讯作者：
Ni, Bing
中科院分区：
文献类型：
--
作者：
Gao, Weiwu;Jia, Zhengcai;Ni, Bing
癌症通常被认为是遗传和表观遗传疾病。尽管许多研究表明表观遗传酶的异常结构、功能或表达水平导致许多肿瘤类型，但表观遗传机制如何参与B型肝炎病毒（HBV）诱导的肝细胞癌（HCC）仍不清楚。
Cancer is typically considered as a genetic and epigenetic disease. Although numerous studies have indicated that an aberrant structure, function, or expression level of epigenetic enzymes contribute to many tumor types, precisely how the epigenetic mechanisms are involved in the hepatitis B virus (HBV)‐induced hepatocellular carcinoma (HCC) remains unknown.