Successful verbal retrieval in elderly subjects is related to concurrent hippocampal and posterior cingulate activation
Successful verbal retrieval in elderly subjects is related to concurrent hippocampal and posterior cingulate activation
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DOI：
10.1159/000094558
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Grodd, Wolfgang
中科院分区：
文献类型：
--
作者：
Heun, Reinhard;Freymann, Katrin;Grodd, Wolfgang
目的：记忆力减退和海马萎缩是阿尔茨海默病的两个主要方面。采用反应相关的功能磁共振成像设计，我们调查了成功的言语提取和并发的大脑激活在不同阶段的认知衰退的老年受试者之间的关系。我们选择了一个相关的更传统的分类方法，以增加检测相关激活的能力。研究方法：11名阿尔茨海默病患者，21名轻度认知障碍的老年人和29名年龄匹配的认知未受损的受试者学习了180个名词。在用功能磁共振成像测量大脑激活的同时，受试者必须将这180个学习过的词和180个新的干扰词分类为已知的或新的。反应相关的功能磁共振成像分析被用来确定大脑激活的正确记住的单词（命中），与检索成功在整个组。结果：成功的言语提取与左侧海马和扣带回后部的同时激活显著相关。结论：本研究证实了足够的海马功能的重要性，在老年人成功的言语提取。此外，我们的研究支持连接性研究，表明在不同阶段的认知衰退的老年人成功的言语检索过程中，海马和后扣带回之间的功能关系。版权所有（C）2006 S. Karger AG，巴塞尔。
Objective: Memory decline and hippocampal atrophy are two major aspects of Alzheimer's disease. Using a response-related fMRI design, we investigated the relationship between successful verbal retrieval and concurrent cerebral activation in elderly subjects in different stages of cognitive decline. We chose a correlational over the more traditional categorical approach to increase the power of detecting relevant activations. Methods: Eleven subjects with Alzheimer's disease, 21 elderly subjects with mild cognitive impairment, and 29 age-matched cognitively unimpaired subjects learned 180 nouns. While measuring brain activation with fMRI, the subjects had to classify these 180 learned plus 180 new distractor words as known or new. Response-related fMRI analysis was used to identify cerebral activation by correctly remembered words ( hits) that correlated with retrieval success in the whole group. Results: Successful verbal retrieval was significantly correlated with concurrent activation of the left hippocampus and posterior cingulate gyrus. Conclusion: The study confirms the importance of adequate hippocampal function for successful verbal retrieval in the elderly. In addition, our study supports connectivity studies indicating a functional relationship between the hippocampus and the posterior cingulate gyrus during successful verbal retrieval in the elderly in different stages of cognitive decline. Copyright (C) 2006 S. Karger AG, Basel.