Transcription factors controlling development and function of innate lymphoid cells.
Transcription factors controlling development and function of innate lymphoid cells.
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DOI：
10.1093/intimm/dxt063
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发表时间：
2014-03
影响因子：
4.4
通讯作者：
Y. Tanriver;A. Diefenbach
中科院分区：
文献类型：
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作者：
Y. Tanriver;A. Diefenbach
先天淋巴样细胞（Innate lymphoid cells, ILCs）是一类异质性淋巴细胞，在上皮表面的组织稳态中起重要作用。在脾脏和淋巴结中很少发现，但即使在稳态下，肠粘膜中也可以发现大量。在那里，它们代表了抵御入侵病原体的第一道防线，并有助于淋巴器官形成、组织修复，当被不当激活时，还有助于免疫病理。这些细胞的谱系特异性发育、功能和维持依赖于一组有限的转录因子，这些转录因子部分是脊椎动物进化过程中多样化和选择的结果。转录因子的差异表达调节着独特的发育程序，使不同的ILC亚群具有特定的效应功能。尽管存在这种分工，但ilc被认为具有共同的起源，因为它们都是共同淋巴祖细胞的后代，依赖于各种细胞因子受体使用的共同γ链（γc），并显示出对转录调节因子Id2 （DNA结合抑制剂2）的发育需求。在此，我们回顾了ilc发育和功能所需的转录程序，并概述了ilc表达的转录因子和细胞因子的进化。
Innate lymphoid cells (ILCs) are a heterogeneous group of lymphocytes, which play an important role in tissue homeostasis at epithelial surfaces. They are scarce in spleen and lymph nodes, but substantial numbers can be found in the intestinal mucosa even at steady state. There, they represent the first line of defence against invading pathogens and contribute to lymphorganogenesis, tissue repair and, when inappropriately activated, immune pathology. Lineage-specific development, function and maintenance of these cells depend on a restricted set of transcription factors that partially emerged as a result of diversification and selection during vertebrate evolution. The differential expression of transcription factors regulates unique developmental programs, which endow the different ILC subsets with specific effector functions. Despite this division of labour, ILCs are considered to share a common origin, as they all are progeny of the common lymphoid progenitor, rely on the common γ-chain (γc) used by various cytokine receptors and show a developmental requirement for the transcriptional regulator Id2 (inhibitor of DNA binding 2). Here, we review the transcriptional programs required for the development and function of ILCs and give an overview of the evolution of transcription factors and cytokines expressed by ILCs.