The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival
The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival
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DOI：
10.1002/ijc.27420
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发表时间：
2012-09-01
影响因子：
6.4
通讯作者：
Whiteman, David C.
中科院分区：
文献类型：
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作者：
Thrift, Aaron P.;Nagle, Christina M.;Whiteman, David C.
人口和生活方式因素，特别是吸烟和饮酒，是食管鳞状细胞癌（ESCC）的明确病因；然而，人们对这些因素对生存率的影响知之甚少。我们纳入了所有301例ESCC患者，这些患者被招募到澳大利亚一项基于人群的食管癌病例对照研究中。在诊断时获得有关人口和生活方式因素的详细信息，并使用国家死亡指数确定死亡人数。全因死亡率的中位随访时间为6.4年。根据Cox比例风险模型计算风险比（hr）和95%置信区间（95% CI），并根据年龄、性别、预处理AJCC肿瘤分期、治疗和合并症的存在进行调整。113例（71%）患者在随访期间死亡。终生高酒精摄入量与较差的生存率独立相关。相对于终生不饮酒者和饮酒者
Demographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of esophageal squamous cell carcinoma (ESCC); however, little is known about the effect of these factors on survival. We included all 301 patients with incident ESCC, recruited into a population-based casecontrol study of esophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow-up for all-cause mortality was 6.4 years. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pretreatment AJCC tumor stage, treatment and presence of comorbidities. Two hundred and thirteen patients (71%) died during follow-up. High lifetime alcohol consumption was independently associated with poor survival. Relative to life-long nondrinkers and those consuming