The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent
The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent
复制标题
DOI：
10.1016/j.neurobiolaging.2010.07.015
复制
发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Verhey, Frans R. J.
中科院分区：
文献类型：
--
作者：
Jacobs, Heidi I. L.;Visser, Pieter Jelle;Verhey, Frans R. J.
轻度认知障碍（MCI）患者的白色高信号（WMH）与执行功能受损有关，尽管有相互矛盾的研究结果。本研究的目的是检查WMH位置是否影响WMH和MCI参与者（55-90岁）执行功能之间的关系，在欧洲多中心的记忆诊所为基础的MIA研究，在基线时进行MRI扫描（N = 337）。进行线性混合模型分析，以测试WMH损害之间的关联在三个网络（额顶叶，额皮质下和额顶叶皮质下网络）和执行功能的变化超过3年的时间。额顶叶和额顶叶-皮质下网络中的WMH与执行功能下降相关。然而，额叶皮层下网络与执行功能的变化无关，我们的研究结果表明，顶叶WMH是一个显着的贡献者在MCI的执行下降和WMH在支持认知功能的大脑网络的调查提供了一个新的方法来区分稳定的认知下降MCI个人。(C)2012 Elsevier Inc. All rights reserved.
White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the frontal-parietal-subcortical network were associated with decline in executive functioning. However, the frontal-subcortical network was not associated with change in executive functioning.Our results suggest that parietal WMH are a significant contributor to executive decline in MCI and that investigation of WMH in the cerebral networks supporting cognitive functions provide a new way to differentiate stable from cognitive declining MCI individuals. (C) 2012 Elsevier Inc. All rights reserved.