[Histopathological changes of gallbladder and liver parenchyma in symptomatic cholelithiasis].
[Histopathological changes of gallbladder and liver parenchyma in symptomatic cholelithiasis].
复制标题
症状性胆石症胆囊及肝实质的组织病理学改变
DOI：
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发表时间：
1993
影响因子：
0.6
通讯作者：
W. Stock
中科院分区：
文献类型：
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作者：
A. Badke;W. Schwenk;B. Böhm;W. Stock
在一项对1101例（302例男性，799例女性;平均年龄56.7 [19-88]岁）有症状的胆石症患者进行的回顾性研究中，这些患者接受了择期胆囊切除术和术中肝活检，组织学检查显示96.7%的胆囊有炎症变化，94.5%的慢性纤维化胆囊炎和8.8%的重度胆囊炎。27.9%的患者出现临床相关的肝实质改变，最常见的是肝内胆管炎（21.8%）。后者在胆总管结石中比孤立性胆囊结石更常见。27例患者有严重肝病体征，即病毒性肝炎、肝硬化或脂肪肝。由于胆石症的胆囊几乎总是发炎的，胆囊切除术是治疗的选择。肝活组织检查可显示肝实质的临床相关改变，这并不罕见。这将是有用的信息，特别是在术后持续存在的症状的管理。
In a retrospective study of 1101 patients (302 men, 799 women; mean age 56,7 [19-88] years) with symptomatic cholelithiasis who had undergone elective cholecystectomy and intraoperative liver biopsy, histological examination revealed inflammatory changes in the gallbladder in 96.7%, chronic fibrotic cholecystitis in 94.5% and a severe form of cholecystitis in 8.8%. Clinically relevant changes in the liver parenchyma were present in 27.9%, most frequently intrahepatic cholangitis (21.8%). The latter was significantly more common in choledocholithiasis than in isolated cholecystolithiasis. 27 patients had signs of severe liver disease, namely viral hepatitis, cirrhosis or fatty liver. Since the gall-bladder in cholelithiasis is almost always inflamed, cholecystectomy is the treatment of choice. Not uncommonly liver biopsy will reveal clinically relevant changes in the liver parenchyma. This will be useful information, especially in the management of symptoms which persist postoperatively.