Zimelidine‐induced variations in alcohol intake by nondepressed heavy drinkers
Zimelidine‐induced variations in alcohol intake by nondepressed heavy drinkers
复制标题
齐美立定引起非抑郁重度饮酒者的酒精摄入量变化
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
K. Sykora
中科院分区：
文献类型：
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作者：
C. Naranjo;E. Sellers;C. Roach;Denise V Woodley;M. Sanchez;K. Sykora
在一项双盲交叉实验中，13名健康男性、非抑郁的重度饮酒者被随机分配接受齐美利定或安慰剂，测试了齐美利定（一种特异性5-羟色胺再摄取抑制剂）对酒精摄入量的影响。有5个2周的实验期（基线、安慰剂1和2以及齐美利定1和2）。3例受试者因疑似不良反应而中止治疗，另外3例受试者退出。因此，13例受试者参与了至少两个实验药物阶段，仅10例参与了所有阶段。在13名受试者中，齐美利定增加了禁欲天数，减少了每日饮酒量，而在10名受试者中，只有禁欲天数增加。受试者未报告不良酒精致敏反应。Spielberger状态焦虑测试评分和抑郁评分（蒙哥马利/Asberg和汉密尔顿）在研究开始时和整个研究期间均较低。我们的数据表明，zimelidine通过与以前测试的药物不同的机制来改变酒精摄入量，可能是通过调节控制饮酒的中枢神经机制。
The effect of zimelidine, a specific serotonin‐reuptake inhibitor, on alcohol intake was tested in 13 healthy male, nondepressed heavy drinkers who were randomly allocated to receive zimelidine or placebo in a double‐blind, crossover experiment. There were five 2‐wk experimental periods (baseline, placebo 1 and 2, and zimelidine 1 and 2). Treatment was discontinued in three subjects due to a suspected adverse reaction and three other subjects dropped out. Thus, 13 subjects participated in at least two experimental drug periods and only 10 participated in all the periods. In the 13 subjects zimelidine increased the days of abstinence and decreased the daily number of drinks consumed, whereas in the 10 subjects only the number of days of abstinence increased. Subjects did not report aversive alcohol‐sensitizing reactions. Spielberger state‐anxiety test scores and depression scores (Montgomery/Asberg and Hamilton) were low at the beginning and throughout the study. Our data suggest that zimelidine modifies alcohol intake by a different mechanism than previously tested drugs, possibly by modulating the central neural mechanism that controls drinking of alcohol.