T-cell-depleted autologous bone marrow transplantation therapy: analysis of immune deficiency and late complications.
T-cell-depleted autologous bone marrow transplantation therapy: analysis of immune deficiency and late complications.
复制标题
T细胞耗尽的自体骨髓移植治疗：免疫缺陷和晚期并发症的分析。
作者：
K. Anderson;R. Soiffer;R. Delage;T. Takvorian;A. Freedman;S. Rabinowe;L. Nadler;K. Dear;L. Heflin;P. Mauch
14 名 T 细胞源性白血病和淋巴瘤患者接受了大剂量放化疗和抗 T 细胞单克隆抗体治疗的自体骨髓移植 (ABMT)。所有患者要么处于敏感复发状态，要么具有不良预后特征，其中 5 名患者有骨髓受累病史。患者之前平均接受过 2 种（1 至 3）种化疗方案； 10例患者接受局部放射治疗。高剂量消融治疗后，ABMT 后中位 23 天（13 至 48）天和 26 天（15 至 43）天分别观察到大于 500 个/mm3 的粒细胞和大于 20,000 个未输血的血小板/mm3。正如其他系列中所见，在 AMBT 后的前 1 至 2 个月内注意到自然杀伤 (NK) 细胞、T 细胞（主要是 T8+）和单核细胞。中位无病生存期为 10.1 个月，T 型急性淋巴细胞白血病或淋巴母细胞淋巴瘤患者为 5.9 个月，T 型非霍奇金淋巴瘤 (NHL) 患者为 25.6 个月。中毒现象常见且严重。 36% 的患者在 BMT 后早期出现菌血症。晚期并发症包括与移植物抗宿主病一致的皮疹；带状疱疹、肝炎和卡氏肺囊虫感染；以及 Epstein-Barr 病毒相关淋巴细胞增殖综合征的发生。我们的研究结果表明，接受 T 耗尽 ABMT 的患者存在严重的免疫缺陷，但 T 细胞和 NK 细胞的表型重建并未反映出来。功能缺陷的表征可能有助于开发减少 AMBT 对这些患者的长期毒性的方法。
Fourteen patients with T-cell-derived leukemia and lymphoma underwent high-dose chemoradiotherapy and anti-T-cell monoclonal antibody-treated autologous bone marrow transplantation (ABMT). All patients were either in sensitive relapse or had adverse prognostic features, and five patients had a history of bone marrow involvement with disease. Patients received a median of 2 (1 to 3) prior chemotherapy regimens; 10 patients received local radiotherapy. After high-dose ablative therapy, greater than 500/mm3 granulocytes and greater than 20,000 untransfused platelets/mm3 were noted at a median of 23 (13 to 48) and 26 (15 to 43) days post-ABMT, respectively. Natural killer (NK) cells, T cells (predominantly T8+), and monocytes were noted within the first 1 to 2 months post-AMBT, as seen in other series. Disease-free survival was a median of 10.1 months, 5.9 months for patients with T acute lymphoblastic leukemia or lymphoblastic lymphoma and 25.6 months for patients with T non-Hodgkin's lymphoma (NHL). Toxicities were common and severe. Thirty-six percent of patients developed bacteremias early post-BMT. Late complications included a skin rash consistent with graft versus host disease; infections with Herpes zoster, hepatitis, and Pneumocystis carinii; and the development of Epstein-Barr virus associated lymphoproliferative syndrome. Our findings suggest that patients who have undergone T-depleted ABMT have a profound immunodeficiency not reflected in the phenotypic reconstitution of the T and NK cells. Characterization of the functional deficiency may facilitate the development of methods to reduce the long-term toxicity of AMBT in these patients.
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抗 B 细胞单克隆抗体净化的自体骨髓移植治疗 B 细胞非霍奇金淋巴瘤：表型重建和 B 细胞功能。
影响因子：
20.3
作者：
Pedrazzini,A;Freedman,AS;Andersen,J;Heflin,L;Anderson,K;Takvorian,T;Canellos,GP;Whitman,J;Coral,F;Ritz,J
通讯作者：
Ritz,J
非霍奇金淋巴瘤的自体骨髓移植：单克隆抗体加补体用于离体骨髓治疗。
DOI：
10.1016/s0002-9343(88)80029-9
发表时间：
1988
期刊：
The American journal of medicine
影响因子：
--
作者：
Hurd,DD;LeBien,TW;Lasky,LC;Haake,RJ;Ramsay,NK;Kim,TH;Levine,EG;McGlave,PB;Bloomfield,CD;Peterson,BA
通讯作者：
Peterson,BA
弥漫性大细胞淋巴瘤免疫型的预后意义：T 细胞和 B 细胞表型的比较研究。
影响因子：
20.3
作者：
Lippman,SM;Miller,TP;Spier,CM;Slymen,DJ;Grogan,TM
通讯作者：
Grogan,TM
识别接受 m-BACOD 或 M-BACOD 治疗的大细胞淋巴瘤患者的主要预后亚组。
影响因子：
39.2
作者：
Shipp,MA;Harrington,DP;Klatt,MM;Jochelson,MS;Pinkus,GS;Marshall,JL;Rosenthal,DS;Skarin,AT;Canellos,GP
通讯作者：
Canellos,GP
急性淋巴细胞白血病第二次或后续缓解患者的自体骨髓移植：单克隆抗体 BA-1、BA-2 和 BA-3 加补体治疗骨髓的结果。
影响因子：
20.3
作者：
Ramsay,N;LeBien,T;Nesbit,M;McGlave,P;Weisdorf,D;Kenyon,P;Hurd,D;Goldman,A;Kim,T;Kersey,J
通讯作者：
Kersey,J