Recent research on the growth plate: Recent insights into the regulation of the growth plate.
Recent research on the growth plate: Recent insights into the regulation of the growth plate.
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DOI：
10.1530/jme-14-0022
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发表时间：
2014-08
影响因子：
3.5
通讯作者：
Baron J
中科院分区：
文献类型：
--
作者：
Lui JC;Nilsson O;Baron J
对于大多数骨骼，伸长主要由生长板处的软骨形成驱动。这一过程是软骨细胞增殖、肥大和细胞外基质分泌的结果，并由局部旁分泌因子的复杂网络精心编排，并由内分泌因子调节。我们在这里回顾最近的进展，在了解生长板生理。这些进展包括研究生长板中大量基因表达模式的新方法，使用微切割和微阵列。这种方法已与全基因组关联研究相结合，以提供对人类生长板调控的见解。我们还回顾了最近的研究，阐明骨形态发生蛋白，成纤维细胞生长因子，C型利钠肽，抑制细胞因子信号在生长板软骨形成和纵向骨生长的局部调节的作用。
For most bones, elongation is driven primarily by chondrogenesis at the growth plates. This process results from chondrocyte proliferation, hypertrophy, and extracellular matrix secretion and is carefully orchestrated by complex networks of local paracrine factors and modulated by endocrine factors. We review here recent advances in the understanding of growth plate physiology. These advances include new approaches to study expression patterns of large numbers of genes in the growth plate, using microdissection followed by microarray. This approach has been combined with genome-wide association studies to provide insights into the regulation of the human growth plate. We also review recent studies elucidating the roles of bone morphogenetic proteins, fibroblast growth factors, C-type natriuretic peptide, and suppressor of cytokine signaling in the local regulation of growth plate chondrogenesis and longitudinal bone growth.