Growth hormone stimulates adrenal steroidogenesis in the fetus
Growth hormone stimulates adrenal steroidogenesis in the fetus
复制标题
生长激素刺激胎儿肾上腺类固醇生成
作者：
U. Devaskar;S. Devaskar;S. Voina;N. Velayo;M. Sperling
妊娠晚期胎儿血浆中皮质类固醇的“激增”与分娩的开始以及肺、肝、肾上腺髓质和甲状腺等器官中酶系统的成熟有关1 -5。但在所有研究的物种中，胎儿分泌增加的机制仍不清楚。促肾上腺皮质激素（ACTH）是胎儿和成年期肾上腺皮质细胞生长和分泌功能的主要调节因子6。然而，在绵羊或人类皮质类固醇激增之前，没有观察到胎儿血浆ACTH增加7，8，尽管已经提出了不同胎龄胎儿肾上腺皮质对ACTH的不同反应性和肾上腺外抑制因子的可能作用9 -12。α-促黑素细胞激素（αMSH）对胎儿肾上腺皮质功能可能产生的类固醇生成作用存在争议13 -16，我们无法在胎儿羔羊或家兔中证明任何此类作用17，18。催乳素和生长激素（GH）可增强ACTH在成年大鼠中的类固醇生成作用19 -22，但催乳素在胎鼠中没有这种作用17。我们已经研究了GH的类固醇生成特性，并在这里报告，它刺激肾上腺类固醇生成胎儿，但不是母兔在体外和胎儿，但不是母羊在体外和体内。
The ‘surge’ of corticosteroid in fetal plasma during late gestation has been implicated in the initiation of parturition and the maturation of enzyme systems in organs such as the lung, liver, adrenal medulla and thyroid1–5. But in all species studied, the mechanism responsible for increased secretion in the fetus remains unclear. The hormone adrenocorticotropin (ACTH) is well established as the primary regulator of adrenocortical cellular growth and secretory function during fetal and adult life6. However, no increase in fetal plasma ACTH has been observed before the corticosteroid surge in sheep or humans7,8, although differential responsiveness of the fetal adrenal cortex to ACTH at various gestational ages and a possible role of extra-adrenal inhibitory factors have been proposed9–12. The possible steroidogenic effect of α-melanocyte-stimulating hormone (αMSH) on fetal adrenocortical function is controversial13–16, and we could not demonstrate any such action in fetal lamb or rabbit17,18. Prolactin and growth hormone (GH) potentiate the steroidogenic effect of ACTH in adult rats19–22 but prolactin had no such effect in fetal lamb17. We have investigated the steroidogenic properties of GH, and report here that it stimulates adrenal steroidogenesis in the fetal but not maternal rabbit in vitro and in fetal but not maternal sheep in vitro as well as in vivo.
绵羊围产期心血管对α-黑素细胞刺激激素的反应。
影响因子：
3.6
作者：
Llanos,AJ;Seron-Ferre,M;Ramachandran,J;Creasy,RK;Heymann,MA;Rudolph,AM
通讯作者：
Rudolph,AM