COMPARISON OF AN OCCLUSIVE AND A SEMI-OCCLUSIVE DRESSING AND THE EFFECT OF THE WOUND EXUDATE UPON KERATINOCYTE PROLIFERATION
COMPARISON OF AN OCCLUSIVE AND A SEMI-OCCLUSIVE DRESSING AND THE EFFECT OF THE WOUND EXUDATE UPON KERATINOCYTE PROLIFERATION
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DOI：
10.1097/00005373-198907000-00004
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发表时间：
1989-07-01
影响因子：
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通讯作者：
STAIANOCOICO, L
中科院分区：
文献类型：
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作者：
MADDEN, MR;NOLAN, E;STAIANOCOICO, L
对 58 名患者进行了三项连续研究，评估咬合对部分皮层伤口愈合的影响。镜像供体部位用闭塞水胶体敷料 (HCD) (DuoDerm IN) 覆盖，并与细网纱布进行比较，随后将 HCD 与半闭塞聚氨酯薄膜敷料 (Op-site IN) 进行比较。此外，部分烧伤创面用HCD覆盖，其余烧伤创面用磺胺嘧啶银治疗。使用 HCD 治疗的供体部位和烧伤创面的愈合速度明显快于用细网纱布或磺胺嘧啶银覆盖的部位（p < 0.001），并且疼痛也较少。 HCD 和聚氨酯薄膜是等效的。闭合伤口未出现临床感染。将在供体部位的 DuoDerm 和 Op-site 下方收集的渗出液添加到组织培养系统中，导致角质形成细胞增殖适度增加。然而，HCD 下烧伤创面的渗出液导致细胞增殖显着增加 (p<0.001)。
Three consecutive studies were performed in 58 patients evaluating the effect of occlusion on the healing of partial-thickness wounds. Mirror-image donor sites were covered with the occlusive hydrocolloid dressing (HCD)(DuoDerm IN) and compared to fine mesh gauze, and the HCD was subsequently compared to a semi-occlusive dressing of polyurethane film,(Op-site IN). In addition, partial-thickness burn wounds were covered with the HCD and the remaining burn wound was treated with silver sulfadiazine. The donor sites and burn wounds treated with HCD healed significantly faster than those covered with fine mesh gauze or silver sulfadiazine (p< 0.001) and with less pain. The HCD and polyurethane film were equivalent. There were no clinical infections with the wounds that were occluded. The exudate collected beneath the DuoDerm and Op-site on donor sites was added to the tissue culture system and resulted in a modest increase in keratinocyte proliferation. However, the exudate from burn wounds under HCD resulted in a marked increase in cell proliferation (p< 0.001).