Treatment of psychiatric symptoms among offspring of parents with bipolar disorder.
Treatment of psychiatric symptoms among offspring of parents with bipolar disorder.
复制标题
父母患有双相情感障碍的后代精神症状的治疗。
DOI：
10.1007/s40501-017-0126-9
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发表时间：
2017
影响因子：
--
通讯作者：
Singh,ManpreetK
中科院分区：
文献类型：
--
作者：
Zalpuri,Isheeta;Singh,ManpreetK
回顾的目的双相情感障碍是高度家族性的，并有一个旷日持久和诊断混乱的前驱症状。这篇综述对最近发表的有关治疗双相情感障碍高危子女精神症状的文献进行了批判性评估。最近的发现非药物治疗方案，包括心理治疗，通过良好的睡眠、饮食和运动卫生来提高韧性，以及补充omega-3脂肪酸是高危子女的重要一线干预措施。用情绪稳定剂和非典型抗精神病药物治疗这一人群已经取得了一些成功；然而，这些结果还没有在随机对照试验中复制。尽管在早期识别双相情感障碍父母的子女的症状方面取得了一些进展，但很少有证据支持对这些高危青年进行治疗，以防止精神症状发展到阈值双相情感或其他精神障碍。有必要进行前瞻性和随机化的试验和研究，以确定可靠的生物标志物，使这些年轻人的治疗个体化。
Purpose of reviewBipolar disorder is highly familial and has a protracted and diagnostically confusing prodrome. This review critically evaluates recently published literature relevant to the treatment of psychiatric symptoms in high-risk offspring of parents with bipolar disorder.Recent findingsNon-pharmacological treatment options including psychotherapy, resilience promotion through good sleep, diet, and exercise hygiene, and omega-3 fatty acid supplementation are important first-line interventions for high-risk offspring. There has been some success in treating this population with open-label trials with mood stabilizers and atypical antipsychotics; however, these results have not been replicated in randomized controlled trails.SummaryDespite some progress in early identification of symptoms in offspring of parents with bipolar disorder, there is scarce evidence supporting the treatment of these high-risk youth to prevent psychiatric symptoms from progressing to threshold bipolar or other psychiatric disorders. There is a need for prospective and randomized trials and research that identifies reliable biomarkers to individualize treatments for these youth.