Association of functional variants of PTPN22 and tp53 in psoriatic arthritis:: a case-control study
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis:: a case-control study
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DOI：
10.1186/ar1880
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Rahman, P
中科院分区：
文献类型：
--
作者：
Butt, C;Peddle, L;Rahman, P
最近的研究表明 PTPN22 和 tp53 与多种自身免疫性疾病（包括类风湿性关节炎）的易感性有关，表明这些基因对于维持免疫稳态很重要。由于自身免疫性疾病可能具有相似的易感位点，因此对银屑病关节炎 (PsA) 中这些基因的研究具有潜在的相关性。因此，我们在来自加拿大纽芬兰的同质白种人 PsA 队列和来自加拿大多伦多的混合白种人 PsA 队列中研究了 PTPN22 和 tp53 的已知编码多态性。我们仅在多伦多人群中观察到 PTPN22 的 R620W 变体与 PsA 存在中度关联。由于有关 PTPN22 与 PsA 关联的研究结果相互矛盾，因此有必要在其他 PsA 人群中进行进一步研究。
Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.